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Lancet Diab & Endo：依帕列净二线降糖不劣于格列美脲

2014-07-18 伊文 中华医学会糖尿病学分会

依帕列净降糖格列美脲
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近期发表的一项为期104周的随机、活性药物对照、双盲、Ⅲ期临床研究表明，在2型糖尿病患者中，当二甲双胍治疗失败时，加用SGLT2抑制剂依帕列净对HbA1c的降低效果不劣于加用格列美脲。两种联用策略的不良反应和严重不良反应发生率均无显著差异，依帕列净组的低血糖事件发生率明显低于格列美脲组（2% vs 24%）。 原始出处： Ridderstråle M

近期发表的一项为期104周的随机、活性药物对照、双盲、Ⅲ期临床研究表明，在2型糖尿病患者中，当二甲双胍治疗失败时，加用SGLT2抑制剂依帕列净对HbA1c的降低效果不劣于加用格列美脲。两种联用策略的不良反应和严重不良反应发生率均无显著差异，依帕列净组的低血糖事件发生率明显低于格列美脲组（2% vs 24%）。

原始出处：

Ridderstråle M1, Andersen KR2, Zeller C3, Kim G4, Woerle HJ4, Broedl UC4; on behalf of the EMPA-REG H2H-SU trial investigators.Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial.Lancet Diabetes Endocrinol. 2014 Jun 16. pii: S2213-8587(14)70120-2. doi: 10.1016/S2213-8587(14)70120-2. [Epub ahead of print]

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    2015-04-11 x35042875

    糖尿病肾病进展风险的关系没有发现。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=20693, encodeId=3eec2069330, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:31:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636914, encodeId=dafd163691447, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Apr 19 08:46:00 CST 2015, time=2015-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1827841, encodeId=02cd182e84180, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 13 00:46:00 CST 2015, time=2015-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417281, encodeId=aaf3141e28122, content=<a href='/topic/show?id=266826884bf' target=_blank style='color:#2F92EE;'>#依帕列净#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26884, encryptionId=266826884bf, topicName=依帕列净)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0353248055, createdName=DEXTER3140, createdTime=Sun Jul 20 01:46:00 CST 2014, time=2014-07-20, status=1, ipAttribution=)]
    2015-04-19 ms9608593228839890

    #DIA#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=20693, encodeId=3eec2069330, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:31:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636914, encodeId=dafd163691447, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Apr 19 08:46:00 CST 2015, time=2015-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1827841, encodeId=02cd182e84180, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 13 00:46:00 CST 2015, time=2015-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417281, encodeId=aaf3141e28122, content=<a href='/topic/show?id=266826884bf' target=_blank style='color:#2F92EE;'>#依帕列净#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26884, encryptionId=266826884bf, topicName=依帕列净)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0353248055, createdName=DEXTER3140, createdTime=Sun Jul 20 01:46:00 CST 2014, time=2014-07-20, status=1, ipAttribution=)]
    2015-01-13 howi

    #Lancet#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=20693, encodeId=3eec2069330, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:31:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636914, encodeId=dafd163691447, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Apr 19 08:46:00 CST 2015, time=2015-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1827841, encodeId=02cd182e84180, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 13 00:46:00 CST 2015, time=2015-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417281, encodeId=aaf3141e28122, content=<a href='/topic/show?id=266826884bf' target=_blank style='color:#2F92EE;'>#依帕列净#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26884, encryptionId=266826884bf, topicName=依帕列净)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0353248055, createdName=DEXTER3140, createdTime=Sun Jul 20 01:46:00 CST 2014, time=2014-07-20, status=1, ipAttribution=)]
    2014-07-20 DEXTER3140

    #依帕列净#

    0

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近期发表的一项囊括10项随机对照研究的Meta分析表明，对于2型糖尿病患者，与安慰剂相比，钠葡萄糖共同转运蛋白2(SGLT-2)抑制剂依帕列净(empagliflozin)除了能有效降低血糖外，还有助于减轻体重和降低血压。(Diabetes Obes Metab. 2014年4月26日在线版)在该分析中，依帕列净以10 mg或25 mg应用对HbA1c水平的降低效果均显著优于安慰剂，其中25 mg