BMJ:酒精销售管制的“严”和“松”与居民心脏病风险相

2016-06-17 Seven L 译 MedSci原创

研究者使用使用酒精销售法的差异进行了一项观察性队列研究,探究酒精摄入量与心脏病的关系,并作为一种自然实验。该研究纳入了2005-2010年间≥21岁的1106968名住院患者,根据所在区域酒精的限制情况分为“湿”县(没有酒精的限制)和“干”县(酒精销售全面禁止)。酒精滥用和酒精性肝病的流行率发生率数据用于验证分析。研究的主要心血管终点为房颤、急性心肌梗死和充血性心力衰竭。数据显示,湿县居民酒精滥用

研究者使用酒精销售法的差异进行了一项观察性队列研究,探究酒精摄入量与心脏病的关系,并作为一种自然实验。

该研究纳入了2005-2010年间≥21岁的1106968名住院患者,根据所在区域酒精的限制情况分为“湿”区(没有酒精的限制)和“干”区(酒精销售全面禁止)。酒精滥用和酒精性肝病的流行率发生率数据用于验证分析。研究的主要心血管终点为房颤、急性心肌梗死和充血性心力衰竭。

数据显示,湿区居民酒精滥用和酒精性肝病的患病率发生率更高。多变量校正后,相对于干区,湿区居民房颤患病率更高(OR=1.05, 95% CI 1.01 - 1.09; P=0.007),发病率更高(HR=1.07, 1.01 - 1.13; P=0.014);不过心肌梗死的患病率(OR=0.83, 0.79 - 0.87; P<0.001)和发病率(HR=0.91, 0.87 - 0.99; P=0.019)更低;充血性心力衰竭的患病率(OR=0.87, 0.84 to 0.90; P<0.001)也更低。从干区到湿区的转换,有更高的酒精滥用、酒精性肝病、房颤和充血性心脏衰竭,但是心肌梗死方面没有统计学意义的差异。

研究表明,获取酒精越便捷与更多的房颤和更少的心肌梗死和充血性心脏衰竭有关,虽然酒精销售自由化后短时间内居民的充血性心脏衰竭风险增加。

原始出处:

Jonathan W Dukes,Thomas A Dewland, et al.Access to alcohol and heart disease among patients in hospital: observational cohort study using differences in alcohol sales laws.BMJ 2016;353:i2714


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    2016-08-25 gaoxiaoe
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    2016-09-11 1e10c84am36(暂无匿称)

    己拜读,受益匪浅

    0

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    2016-08-28 ylzr123

    深度好文,值得学习,赞!

    0

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    2016-06-18 沉心多思

    好文章,值得学习

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