Menopause:白藜芦醇或可缓解绝经女性慢性疼痛

2017-09-07 王立群 环球医学

2017年8月,发表在《Menopause》的一项由澳大利亚科学家进行的研究表明,白藜芦醇补充剂能减少绝经后女性的疼痛。



2017年8月,发表在《Menopause》的一项由澳大利亚科学家进行的研究表明,白藜芦醇补充剂能减少绝经后女性的疼痛。

目的:疼痛是绝经后女性的常见疾病。假设在绝经期由于雌激素下降引起的血管功能障碍在关节变性疾病的发生和进展方面起关键作用,即年龄相关性骨关节炎。研究者评估是否补充白藜芦醇(一种植物雌激素)可以改善绝经后女性常经历的慢性疼痛等方面的健康。

方法:在80名健康绝经后女性中进行了一项为期14周的随机、双盲、白藜芦醇(75mg,每日两次)干预的安慰剂对照试验。在基线和治疗结束时,通过SF-36量表评估健康状况,包括疼痛、绝经期症状、睡眠质量、抑郁症状、情绪状态和生活质量。平均评分量表提供了体现总体的健康情况的复合评分。也评估对高碳酸血症的脑血管舒张反应,作为脑血管功能脑的替代标志物。

结果:与安慰剂治疗相比,白藜芦醇补充后疼痛明显减轻,总体健康状况改善。两方面受益(包括生活质量)与脑血管功能改善相关。

结论:初步研究结果表明,白藜芦醇治疗可能缓解年龄相关性骨关节炎的慢性疼痛。白藜芦醇的使用也可能促进对绝经后妇女的健康认知。进一步研究以阐明潜在的机制是有必要的。

原始出处

Wong RHX, et al. Resveratrol supplementation reduces pain experience by postmenopausal women. Menopause. 2017 Aug;24(8):916-922. doi: 10.1097/GME.0000000000000861.

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    2018-02-06 1e145228m78(暂无匿称)

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