Metabolism:超声脂肪肝指标检测轻度脂肪变性,并与各种肝病的代谢/组织学参数相关!

2017-06-25 xing.T MedSci原创

由此可见,US-FLI可以准确地识别组织严重程度,并与各种脂肪性肝病患者的代谢参数相关。US-FLI是一个筛查脂肪变性和这些代谢健康患者方便和灵活的工具。

脂肪肝是不同类型肝病的共同特征。超声诊断脂肪肝的敏感性和特异性是可变的。半定量超声评分,即超声脂肪肝指标(US-FLI),与非酒精性脂肪性肝病(NAFLD)患者的代谢/组织学变量密切相关。

近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,该研究的主要目的是评估US-FLI在检测不同组织脂肪变性程度的诊断性能,并在352例各种慢性肝病的活检患者(173例丙型肝炎[HCV]患者,23例乙型肝炎[HCV],123例NAFLD和33例其他病因的患者)评估US-FLI与代谢/组织学参数之间的相关性。

研究人员发现采用≥2的临界值,US-FLI可以准确地检测出轻度脂肪变性(组织学上最少为10%)(敏感性为90.1%,特异性为90%),采用≥3的临界值,检测中度脂肪变性(≥30%)(敏感性为86.4%,特异性为92.5%),采用≥5的临界值,检测重度脂肪变性(>66%)(敏感性为88.5%,特异性为87%)。US-FLI与各肝病组脂肪百分比以及与小叶内炎症、ballooning评分、门脉纤维化、NAFLD或HCV患者的分级和分期相关。在整个样本和各肝病组中,US-FLI也与腰围、体重指数和胰岛素抵抗相关。

由此可见,US-FLI可以准确地识别组织严重程度,并与各种脂肪性肝病患者的代谢参数相关。US-FLI是一个筛查脂肪变性和这些代谢健康患者方便和灵活的工具。

原始出处:

Stefano Ballestri,et al. Ultrasonographic fatty liver indicator detects mild steatosis and correlates with metabolic/histological parameters in various liver diseases. Metabolism-Clinical and Experimental.2017. http://dx.doi.org/10.1016/j.metabol.2017.04.003

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    2017-07-15 一闲
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topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Tue Jun 27 04:51:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577172, encodeId=03ff15e7172ce, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Tue Jun 27 04:51:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597970, encodeId=9157159e9709d, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 04:51:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-10-19 guojianrong
  5. 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style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 04:51:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-29 大爰

    好文章学习了谢谢分享!

    0

  6. 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style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 04:51:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-28 往日如昨

    继续学习中谢谢

    0

  7. 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style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 04:51:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-27 ylzr123

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

  8. 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style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 04:51:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-27 huangdf
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    2017-06-27 闆锋旦