JCEM:TSH和FT4在先天性中枢性甲状腺功能减退症和轻度先天性甲状腺功能减低症中的浓度

2018-01-10 MedSci MedSci原创

在中枢性甲状腺功能减退症(CeH)中,游离甲状腺素(FT4)浓度低而TSH浓度可能低、正常甚至由于生物活性降低而略微升高。先天性CeH(CCeH)可能是孤立性或多发性垂体激素缺乏症(MPHD)的一部分。

在中枢性甲状腺功能减退症(CeH)中,游离甲状腺素(FT4)浓度低而TSH浓度可能低、正常甚至由于生物活性降低而略微升高。先天性CeH(CCeH)可能是孤立性或多发性垂体激素缺乏症(MPHD)的一部分。

2018年1月9日在JCEM上发表的一篇文章在旨在验证如下假设:1)与具有功能正常的下丘脑-垂体-甲状腺轴的儿童相比,CCeH患儿的TSH浓度具有更多的U型分布;2)患有MPHD的CCeH患儿的TSH浓度高于单独的CCeH患儿。研究人员还研究了FT4的水平是否有助于将CCeH患儿从轻度原发性CH(CH-T)中区分出来。所有在1995-2012年诊断永久性CCeH的患儿都接受了丹麦新生儿筛查TSH和首次诊断TSH和FT4,对照组是TBG缺乏的儿童,并将CCeH中的FT4浓度与TSH值相同范围CH-T的TS4浓度进行比较。

研究人员研究了120名患有CCeH的儿童(孤立的CCeH,N = 50; MPHD,N = 70)和350名对照。筛查TSH浓度无显着差异(p = 0.055),但诊断性TSH值在CCeH组和对照组之间有显着差异(p = 0.037)。与单独的CCeH相比,MPHD的TSH显着更高(p = 0.004)。与轻度CH-T相比,CCeH的FT4浓度显着降低(p <0.0005)。

上述研究结果表明,相比于MPHD的CCeH患儿的TSH浓度,CCeH患儿中的TSH值具有更多的U形分布。与CH-T相比,CCeH患儿的FT4水平显着降低。

原始出处:

Nitash Zwaveling-Soonawala.et al. TSH and FT4 concentrations in congenital central hypothyroidism and mild congenital thyroidal hypothyroidism. J Clin Endocrinol Metab. 2017.

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    2018-01-21 achengzhao
  6. 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    2018-01-12 huirong
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    2018-01-12 xinxin088
  8. 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  9. 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    2018-01-11 虈亣靌

    学习一下谢谢分享

    0

  10. 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