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SCI REP：外周血和肺静脉血循环肿瘤细胞预测非小细胞肺癌患者的长期生存率！

2017-07-11 xing.T MedSci原创

外周血肺静脉循环肿瘤细胞非小细胞肺癌长期生存率
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由此可见，切除的非小细胞肺癌患者PPB和IPVB中CTC计数是TFS和OS的一个独立危险因素。

近日，Scientific reports 杂志上发表了一篇研究文章，研究人员旨在验证一个假设，即术前外周血（PPB）和术中肺静脉血液（IPVB）中循环肿瘤细胞（CTCs）可以预测非小细胞肺癌（NSCLC）患者手术切除后的长期生存率。研究人员采用涂有抗上皮细胞粘附分子（EpCAM抗体）的磁珠通过磁激活细胞分选（MACS）从血液中分离CTCs。通过流式细胞仪定量广谱角蛋白荧光抗体标记的CTCs，量化了连续就诊的23例I至IIIA期切除的非小细胞肺癌患者PPB和IPVB中的CTCs。随访5年后，研究人员评估了这些患者CTCs与预后之间的相关性。在非小细胞肺癌患者中，根据手术中CTC的水平评估了患者结局。非小细胞肺癌患者确定了PPB中 >5CTCs/15ml以及IPVB中 >50CTCs/15ml为高风险组。单变量Cox比例风险回归分析显示在PPB或IPVB中CTC计数是无瘤生存（TFS）和总生存（OS）的独立危险因子。高风险组患者有较短的中位TFS（22个月vs. ＞60个月，P< 0.0012）和OS（27个月vs. >60个月，P＜0.0015）。由此可见，切除

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    2018-04-06 lingaifan

    #非小细胞#

    0

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    2017-12-16 gds2009

    #肺癌患者#

    0

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    2018-04-07 xue8602

    #静脉血#

    0

  4. 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createdName=gds2009, createdTime=Sat Dec 16 15:32:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955302, encodeId=555a195530238, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Sat Apr 07 02:32:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697500, encodeId=9a53169e50058, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue May 29 22:32:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256581, encodeId=c8061256581b8, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312968, encodeId=971c131296831, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494974, encodeId=248b14949e4af, content=<a href='/topic/show?id=449c9e02334' target=_blank style='color:#2F92EE;'>#长期生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97023, encryptionId=449c9e02334, topicName=长期生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5849143329, createdName=w363522452, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578527, encodeId=c01015e852707, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580955, encodeId=36db15809555f, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600828, encodeId=f5bc1600828e5, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2018-05-29 fusion

    #静脉#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2059630, encodeId=db3c2059630e4, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Fri Apr 06 01:32:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990600, encodeId=3c301990600d0, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, 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topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue May 29 22:32:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256581, encodeId=c8061256581b8, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312968, encodeId=971c131296831, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494974, encodeId=248b14949e4af, content=<a href='/topic/show?id=449c9e02334' target=_blank style='color:#2F92EE;'>#长期生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97023, encryptionId=449c9e02334, topicName=长期生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5849143329, createdName=w363522452, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578527, encodeId=c01015e852707, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580955, encodeId=36db15809555f, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600828, encodeId=f5bc1600828e5, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-13 guoyibin

    #生存率#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2059630, encodeId=db3c2059630e4, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Fri Apr 06 01:32:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990600, encodeId=3c301990600d0, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, 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topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue May 29 22:32:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256581, encodeId=c8061256581b8, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312968, encodeId=971c131296831, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494974, encodeId=248b14949e4af, content=<a href='/topic/show?id=449c9e02334' target=_blank style='color:#2F92EE;'>#长期生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97023, encryptionId=449c9e02334, topicName=长期生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5849143329, createdName=w363522452, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578527, encodeId=c01015e852707, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580955, encodeId=36db15809555f, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600828, encodeId=f5bc1600828e5, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-13 hmwwww

    #肿瘤细胞#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2059630, encodeId=db3c2059630e4, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Fri Apr 06 01:32:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990600, encodeId=3c301990600d0, content=<a href='/topic/show?id=5739822223f' target=_blank style='color:#2F92EE;'>#肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82222, encryptionId=5739822223f, topicName=肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, 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topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue May 29 22:32:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256581, encodeId=c8061256581b8, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312968, encodeId=971c131296831, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494974, encodeId=248b14949e4af, content=<a href='/topic/show?id=449c9e02334' target=_blank style='color:#2F92EE;'>#长期生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97023, encryptionId=449c9e02334, topicName=长期生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5849143329, createdName=w363522452, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578527, encodeId=c01015e852707, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580955, encodeId=36db15809555f, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600828, encodeId=f5bc1600828e5, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-13 w363522452

    #长期生存率#

    0

  8. 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target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580955, encodeId=36db15809555f, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600828, encodeId=f5bc1600828e5, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-13 ms3994565386320060

    #外周血#

    0

  9. 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likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494974, encodeId=248b14949e4af, content=<a href='/topic/show?id=449c9e02334' target=_blank style='color:#2F92EE;'>#长期生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97023, encryptionId=449c9e02334, topicName=长期生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5849143329, createdName=w363522452, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578527, encodeId=c01015e852707, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580955, encodeId=36db15809555f, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600828, encodeId=f5bc1600828e5, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-13 thinkibmz_44722599

    #循环肿瘤细胞#

    0

  10. 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likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494974, encodeId=248b14949e4af, content=<a href='/topic/show?id=449c9e02334' target=_blank style='color:#2F92EE;'>#长期生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97023, encryptionId=449c9e02334, topicName=长期生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5849143329, createdName=w363522452, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578527, encodeId=c01015e852707, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580955, encodeId=36db15809555f, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600828, encodeId=f5bc1600828e5, content=<a href='/topic/show?id=973e99390a4' target=_blank style='color:#2F92EE;'>#非小细胞肺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99390, encryptionId=973e99390a4, topicName=非小细胞肺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e0218815946, createdName=zxxiang, createdTime=Thu Jul 13 02:32:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-13 zxxiang

    #非小细胞肺癌患者#

    0

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Clin Cancer Res：一种利用外周血筛检大肠癌的新法或面世

近年来，随着生物芯片技术和血液标本保存技术的不断发展，外周血肿瘤标志物已成为大肠癌研究的热点之一。近期，由复旦大学附属肿瘤医院－梅里埃研究所实验室科研人员完成了对外周血18个基因表达谱检测，结果显示外周血分子标记物检测的灵敏度显著优于传统的FOBT方法。该研究已发表于《临床肿瘤研究》（Clinical Cancer Research）。 大肠癌是一种常见的恶性肿瘤，其发病率在恶性肿瘤中居第三位。

JCLA：外周血细胞图像的白血病谱系细胞和反应性淋巴细胞的特征分析和自动鉴定

自动外周血（PB）图像分析仪通常低估早期骨髓细胞的总数，并与反应性或正常淋巴细胞混淆。因此，它们不能区分骨髓或淋巴样细胞谱系。本研究的的目的是实现反应性淋巴细胞（RLC），淋巴和骨髓细胞的自动鉴别，并通过特征分析获得其形态学模式。