阜外医院赵连成等万人19年随访研究:甘油三酯越高,心脑血管事件风险就越高

2019-02-26 佚名 中国循环杂志

即使血清 LDL-C 目在达到标水平的人仍有心血管事件的残留风险,这可能与甘油三酯(TG)水平升高有关。 阜外医院赵连成等利用中美合作研究资料,对近万人的队列人群进行了长达 19 年的随访,结果表明,基线血清TG水平较高者的冠心病事件和缺血性脑卒中事件发生率显著增加。


即使血清 LDL-C 目在达到标水平的人仍有血管事件的残留风险,这可能与甘油三酯(TG)水平升高有关。

阜外医院赵连成等利用中美合作研究资料,对近万人的队列人群进行了长达 19 年的随访,结果表明,基线血清TG水平较高者的冠心病事件和缺血性脑卒中事件发生率显著增加。

9 434 人纳入最终分析,基线平均年龄(45.8±6.0)岁。

根据基线血清甘油三酯水平的四分位数分为四组(切点值分别为 0.69 mmol/L、0.95 mmol/L、1.36 mmol/L)。

对研究对象平均随访 19 年后,共发生冠心病事件和缺血性脑卒中事件事件 632 例(6.70%)。从 TG 第 1 至第 4分位组,冠心病事件和缺血性脑卒中事件的发生率依次为 4.09%、5.37%、 6.68% 和 10.68%,呈明显上升趋势。

校正其他危险因素分析后发现,随着甘油三酯水平的升高,冠心病事件和缺血性脑卒中事件发生风险呈明显上升趋势,与第 1 分位组相比,第 4 分位组冠心病事件和缺血性脑卒中事件发病风险增加 40%。

进一步分别分析血清甘油三酯水平与冠心病事件和缺血性脑卒中关系时,只发现甘油三酯水平会显著增加缺血性脑卒中的发生风险,而冠心病事件的发生率虽然与甘油三酯水平有显著的正关联,但多因素分析时其关联未达到统计学显著水平。

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    2019-08-25 habb
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