含有DMADDM的根管封闭剂材料可用于预防和治疗顽固性根尖周炎

2019-07-26 不详 网络

主要由微生物感染引起的持续性根尖周炎是牙髓病学家面临的一个关键挑战。二甲基氨基十二烷基甲基丙烯酸酯(DMADDM)是一种经过充分研究和有效的抗菌剂。本研究旨在通过将DMADDM掺入EndoREZ开发一种新型抗菌根管封闭剂,并研究所得材料的性质。将不同质量分数(0,1.25%,2.5%和5%)的DMADDM掺入EndoREZ中,评价所得材料的细胞毒性,顶端密封能力和溶解度。此外,进行直接接触试验,菌

主要由微生物感染引起的持续性根尖周炎是牙髓病学家面临的一个关键挑战。二甲基氨基十二烷基甲基丙烯酸酯(DMADDM)是一种经过充分研究和有效的抗菌剂。本研究旨在通过将DMADDM掺入EndoREZ开发一种新型抗菌根管封闭剂,并研究所得材料的性质。

将不同质量分数(0,1.25%,2.5%和5%)的DMADDM掺入EndoREZ中,评价所得材料的细胞毒性,顶端密封能力和溶解度。此外,进行直接接触试验,菌落形成单位的测定,结晶紫试验,扫描电子显微镜检查和活/死细菌染色,以评价封闭剂对多种细菌(粪肠球菌,嗜铁链球菌,内氏放线菌和嗜酸乳杆菌)在浮游细胞或生物膜中的抗菌作用。进行荧光原位杂交和定量实时聚合酶链反应以评估多物种生物膜的组成。

结果显示,含有DMADDM(1.25%,2.5%)和EndoREZ(0%)的密封剂之间在细胞毒性,顶端密封能力和溶解度方面没有差异。然而,当DMADDM的质量分数增加至5%时,与0%(p <0.05)组相比,发现明显不同的性质。此外,将DMADDM加入密封剂可以极大地改善EndoREZ的抗菌性能。此外,在含有DMADDM的封闭剂中,多种微生态学中粪肠球菌的组成比可以降低。

因此,含有DMADDM的EndoREZ封闭剂材料可被认为在临床应用中用于预防和治疗持续性根尖周炎。

原始出处:

Liu D, Peng X, et al., A novel antibacterial resin-based root canal sealer modified by Dimethylaminododecyl Methacrylate. Sci Rep. 2019 Jul 23;9(1):10632. doi: 10.1038/s41598-019-47032-8.

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