BMC Oral Health:310 nm紫外发光二极管辐照对口腔细菌的杀菌作用

2019-11-28 不详 网络

紫外线(UV)用于皮肤病学中的光疗,而紫外线(UVB)光(约310 nm)对牛皮癣和特应性皮炎有效。另外,已知UVC光(约265nm)具有杀菌作用,但是对于UVB光的杀菌作用知之甚少。在这项研究中,我们研究了UVB发光二极管(LED)辐射对口腔细菌的杀菌作用,以探索使用310 nm UVB-LED辐射装置治疗口腔感染性疾病的可能性。研究人员准备了一种UVB(310 nm)LED装置用于口腔内使用,

紫外线(UV)用于皮肤病学中的光疗,而紫外线(UVB)光(约310 nm)对牛皮癣和特应性皮炎有效。另外,已知UVC光(约265nm)具有杀菌作用,但是对于UVB光的杀菌作用知之甚少。在这项研究中,我们研究了UVB发光二极管(LED)辐射对口腔细菌的杀菌作用,以探索使用310 nm UVB-LED辐射装置治疗口腔感染性疾病的可能性。

研究人员准备了一种UVB(310 nm)LED装置用于口腔内使用,以检查对变形链球菌,sauguinis链球菌,牙龈卟啉单胞菌和核纤梭菌的杀菌作用,并检查对人口腔上皮细胞系(Ca9-22)的细胞毒性。我们还检查了用UVB-LED光照射后Ca9-22细胞产生的一氧化氮和过氧化氢。

结果显示,使用105 nm / cm2的310 nm UVB-LED照射对口腔细菌显示出30-50%的杀菌活性,尽管用265 nm UVC-LED的17.1 mJ /cm2照射完全杀死了细菌。Ca9-22细胞在265 nm UVC-LED的照射下受到严重伤害,但在310 nm UVB-LED的照射下未受到伤害。Ca9-22细胞在310 nm UVB-LED照射下产生一氧化氮和过氧化氢。牙龈卟啉单胞菌通过在培养物中添加少量活性氧而被杀死,但其他细菌对活性氧的敏感性较低。

综上所述,该研究结果表明,窄带UVB-LED辐照对口腔细菌具有弱杀菌作用,但对牙龈上皮细胞毒性低。它的辐射还可以诱导口腔上皮细胞产生ROS,并可以增强对特定牙周病细菌的杀菌活性。它可能作为牙周炎的新辅助疗法有用。

原始出处:

Takada A, Matsushita K, et al., Bactericidal effects of 310 nm ultraviolet light-emitting diode irradiation on oral bacteria. BMC Oral Health. 2017 Jun 6;17(1):96. doi: 10.1186/s12903-017-0382-5.

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    2020-01-22 zhaojie88
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    2020-02-10 小几洁
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1974972, encodeId=9b9819e497216, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Fri Aug 07 08:09:00 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861351, encodeId=c2371861351da, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Jan 22 16:09:00 CST 2020, time=2020-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989652, encodeId=08391989652e5, content=<a href='/topic/show?id=541c239345a' target=_blank style='color:#2F92EE;'>#二极管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23934, encryptionId=541c239345a, topicName=二极管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Fri Aug 07 18:09:00 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020613, encodeId=071c20206138b, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Mon Feb 10 14:09:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392828, encodeId=0d1913928288a, content=<a href='/topic/show?id=73d53833178' target=_blank style='color:#2F92EE;'>#口腔细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38331, encryptionId=73d53833178, topicName=口腔细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, createdName=1508842480_96220437, createdTime=Sat Nov 30 05:09:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593947, encodeId=83f6159394ea0, content=<a href='/topic/show?id=0cb961312d1' target=_blank style='color:#2F92EE;'>#杀菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61312, encryptionId=0cb961312d1, topicName=杀菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ea418191484, createdName=hb2014ye, createdTime=Sat Nov 30 05:09:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621827, encodeId=a695162182e31, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sat Nov 30 05:09:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2019-11-30 hb2014ye
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