Hypertension:强化降压对房颤风险的影响

2020-05-06 MedSci原创 MedSci原创

对患有心血管疾病高风险的高血压患者进行强化降压治疗,达到SBP<120mmHg的目标,有可能降低AF的风险。

对于高血压患者,严格控制血压(BP)是否会降低房颤(AF)的风险仍不确定。近日,高血压领域权威杂志Hypertension上发表了一篇研究文章,研究人员使用收缩压干预试验(SPRINT)的数据(该研究纳入了心血管疾病风险增加的高血压参与者)旨在评估与标准BP降低(收缩压[SBP]目标值<140mmHg)相比,强化降压是否(SBP目标值<120mmHg)是否可以使AF风险降低。

这项分析纳入了8022名参与者(4003名被随机分入强化降压组,而4019名被随机分为标准BP治疗组),这些患者在入组时无AF,并具有可用的基线和随访心电图数据。根据每两年一次研究评估和就诊时记录的标准12导联心电图确定AF情况。

在长达5.2年的随访中,总共随访28322人次每年,发生了206起AF事件。在强化BP降低组中为88例,在标准BP治疗组中为118例。强化降压与新发AF的风险降低26%有关(风险比为0.74 [95%CI为0.56-0.98];P=0.037)。当通过Hommel调整后的P值评估治疗效果与这些亚组之间的相互作用时,SPRINT参与者在按年龄、性别、种族、SBP三分位数、既往心血管疾病和既往慢性肾脏病分层进行预定亚组分析中,这些效应是一致的。

总而言之,对患有心血管疾病高风险的高血压患者进行强化降压治疗,达到SBP<120mmHg的目标,有可能降低AF的风险。

原始出处:

Elsayed Z. Soliman,et al.Effect of Intensive Blood Pressure Lowering on the Risk of Atrial Fibrillation.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.14766

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    2020-05-06 心介

    房颤,临床上碰到很多哦

    0

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