Clin Oral Investig:富含纳米级六偏磷酸钠牙膏的防龋效果

2019-01-02 lishiting MedSci原创

这篇研究的目的是为了评估含六偏磷酸钠(HMPnano)的含氟牙膏对釉质脱矿及原位形成的菌斑生物膜的生物化学组分和不能溶解的胞外多糖(EPS)的影响。

这篇研究的目的是为了评估含六偏磷酸钠(HMPnano)的含氟牙膏对釉质脱矿及原位形成的菌斑生物膜的生物化学组分和不能溶解的胞外多糖(EPS)的影响。

这项交叉型双盲实验包含4个阶段(7 days each),由12名志愿者口含4个牛牙釉质块。采用30%蔗糖(6×/day)诱导致龋。使用以下牙膏处理釉质块3×/day:非F/HMP/HMPnano (安慰剂组), 常规含氟牙膏, 1100 ppm F (1100F), 1100F+0.5% micrometric HMP (1100F/HMP)和1100F+0.5%纳米级HMP (1100F/HMPnano)。检测表面硬度缺失百分比(%SH)、表面硬度的整体缺失(ΔKHN)和釉质的钙、磷和氟。检测釉质块上形成的生物膜的F, Ca, P和不吸收胞外多糖(EPS)浓度。数据使用one-way ANOVA和Student-Newman-Keuls检验进行统计学评估(p<0.001)。

结果显示,在所有组中,1100F/HMPnano可以形成最低的%SH和ΔKHN (p<0.001)。将HMPnano额外添加入1100F显著增加钙的浓度(p<0.001)。与1100F 相比,1100F/HMPnano可以形成更低的EPS值(~70%) (p<0.001),以及增加生物膜内钙和氟的浓度。

结论:与1100F 牙膏相比,1100F/HMPnano在对抗釉质脱矿和原位生物膜的组成上均起到更好的保护作用。

临床意义:这种牙膏对于具有罹患龋齿高风险的患者来说是种有效的选择。

原始出处:

Garcia LSG, Delbem ACB, et al. Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate. Clin Oral Investig. 2018 Dec 11. doi: 10.1007/s00784-018-2773-7.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2051308, encodeId=025b2051308a3, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Jul 21 03:12:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020537, encodeId=8f84202053e90, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Thu Oct 31 07:12:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046714, encodeId=da651046e145c, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Jan 03 00:12:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357022, encodeId=bf0c35e0222f, content=不错的作品,为我们探讨研究提供了方针,必须给点个赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Wed Jan 02 22:48:38 CST 2019, time=2019-01-02, status=1, ipAttribution=)]
    2019-10-31 小几洁
  3. [GetPortalCommentsPageByObjectIdResponse(id=2051308, encodeId=025b2051308a3, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Jul 21 03:12:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020537, encodeId=8f84202053e90, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Thu Oct 31 07:12:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046714, encodeId=da651046e145c, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Jan 03 00:12:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357022, encodeId=bf0c35e0222f, content=不错的作品,为我们探讨研究提供了方针,必须给点个赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Wed Jan 02 22:48:38 CST 2019, time=2019-01-02, status=1, ipAttribution=)]
    2019-01-03 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2051308, encodeId=025b2051308a3, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Jul 21 03:12:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020537, encodeId=8f84202053e90, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Thu Oct 31 07:12:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046714, encodeId=da651046e145c, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Jan 03 00:12:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357022, encodeId=bf0c35e0222f, content=不错的作品,为我们探讨研究提供了方针,必须给点个赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Wed Jan 02 22:48:38 CST 2019, time=2019-01-02, status=1, ipAttribution=)]
    2019-01-02 lietome24

    不错的作品,为我们探讨研究提供了方针,必须给点个赞了!

    0

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