Oral Oncol:手术加术后增强放疗治疗口腔癌的疗效评估

2017-09-14 MedSci MedSci原创

尽管对于口腔鳞状细胞癌(OCSCC)的治疗模式未发生明显改变,然而放射线疗法、手术治疗和影像学技术的不断提高允许我们探究是否手术加术后增强放疗(IMRT)的疗法对OCSCC患者的肿瘤学疗效和存活情况有所改善。

尽管对于口腔鳞状细胞癌(OCSCC)的治疗模式未发生明显改变,然而放射线疗法、手术治疗和影像学技术的不断提高允许我们探究是否手术加术后增强放疗(IMRT)的疗法对OCSCC患者的肿瘤学疗效和存活情况有所改善。研究回顾性调查了2000年至2012年间病理诊断为OCSCC患者的治疗记录,并提取患者的人数统计、疾病和治疗标准。使用Kaplan-Meier方法计算存活曲线。结果显示,研究共分析了289名患者记录。平均的随访时间为35个月。有268名患者病变涉及颈部解剖(93%),其中66%累及颈部结节,而涉及的结节有51%呈囊外扩展的阳性解剖。40名患者接受了诱导化疗,107名患者接受了并发化疗。高危险性临床靶体积的平均剂量为60Gy/30份。5年的局部控制和整体存活率分别为76%和57%。肿瘤侵袭深度>1.5cm的局部治疗失败风险要明显高于≤1.5cm的肿瘤深度(p<0.001)。多元统计分析显示,阳性和未累及颈部解剖(p=0.01)、阳性淋巴管浸润(p=0.006)和侵袭深度>1.5cm (p=0.003)的病患均为较差存活率的独立指征。结论:疾病疗效与历史数据相一致,并

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    2018-04-08 minlingfeng
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    2017-09-23 小几洁
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    2017-09-15 189****7206

    学习了受益匪浅

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