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Science：新型成像技术揭秘癌细胞如何迁移！

2018-05-01 佚名 “细胞”微信号

细胞成像技术亚细胞过程癌症
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一个包括石溪大学癌症研究中心和生物化学和细胞生物学系研究员David Q. Matus博士和Benjamin L. Martin博士的国际研究团队开发了一种联合晶格层光显微术（LLSM）和自适应光学(AO)的新型细胞成像技术，可以对细胞进行高分辨率的成像，同时可以捕捉到亚细胞过程。这项研究发表在《Science》上，研究人员展示了这项技术如何观察不同器官和不同发展时期以及不同条件（如有丝分裂、免疫

一个包括石溪大学癌症研究中心和生物化学和细胞生物学系研究员David Q. Matus博士和Benjamin L. Martin博士的国际研究团队开发了一种联合晶格层光显微术（LLSM）和自适应光学(AO)的新型细胞成像技术，可以对细胞进行高分辨率的成像，同时可以捕捉到亚细胞过程。这项研究发表在《Science》上，研究人员展示了这项技术如何观察不同器官和不同发展时期以及不同条件（如有丝分裂、免疫反应和癌症转移）的细胞表型多样性。

这项AO-LLSM技术为研究癌症和其他疾病的科学家们研究细胞如何运动并适应不同的生理环境提供了新视角。

这篇文章题为“Observing the cell in its native state： Imaging subcellular dynamics in multicellular organisms”，Matus教授和Martin教授使用AO-LLSM技术捕捉并观察了注射到斑马鱼血管中的乳腺癌细胞的行为。

他们成功地对乳腺癌细胞进行了高分辨率的时间延迟摄影，发现了这些癌细胞类似免疫细胞的行为。这些行为包括旋转、卷曲和侵入血管。

“通过观察和表征这些行为（如癌细胞适应白细胞样的行为），我们也许可以发现靶向转移的乳腺癌细胞的新方法。”Matus说道。

原始出处：

Tsung-Li Liu，et al.Observing the cell in its native state： Imaging subcellular dynamics in multicellular organisms.Science.20 Apr 2018：Vol. 360， Issue 6386， eaaq1392

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    2018-05-13 hb2008ye

    #迁移#

    0

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    2018-05-06 chunjianf

    学习了.谢谢分享

    0

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    2018-05-03 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-05-03 yxch36

    #癌细胞#

    0

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    2018-05-03 仁心济世

    #SCIE#

    0

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    2018-05-03 photoman

    #成像技术#

    0

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    2018-05-01 changjiu

    学习一下谢谢

    0

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    2018-05-01 1e0f8808m18(暂无匿称)

    新技术促进医学发展.

    0

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    2018-05-01 1e17414fm02(暂无匿称)

    学习

    0