JAHA:应激超声心动图可预测癌症死亡!

2017-12-12 xing.T MedSci原创

由此可见,SE结果可预测心血管和癌症死亡率。SE可能是癌症或心血管死亡共同危险因素的中介。

应激超声心动图(SE)可以预测心源性死亡,但越来越多的心脏病患者最终死于癌症。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,这项研究的目的是评估SE结果阳性是否可以预测癌症死亡。

在这项采用单中心前瞻性观察数据进行的回顾性分析中,研究人员对1983年至2009年期间接受SE检查的4673例患者进行了评估。所有患者在进行SE检查时均无癌症,并且随访中位数为131个月。研究人员分别分析了预定的研究终点:心血管疾病、癌症和非心血管、非肿瘤死亡与无竞争风险。

1757例患者为SE阳性,2916例患者为SE阴性;869例心血管疾病患者,418例为癌症患者,625为非心血管非肿瘤死亡。相比于SE阴性患者,SE阳性患者25年期间的死亡率较高,主要为心血管疾病(40% vs. 31%,P<0.001)和癌症死亡率(26% vs. 17%,P<0.01)。SE阳性是癌症(病因特异风险比为1.19;95%可信区间为1.16-1.73;P=0.05)和心血管死亡(1.18;95%可信区间为1.03-1.35;P=0.02)较强的预测因子。对竞争风险进行细灰色分析得到了类似的结果。癌症风险在15年后出现分歧,而心血管风险的差异在5年后就已经显著存在。

由此可见,SE结果可预测心血管和癌症死亡率。SE可能是癌症或心血管死亡共同危险因素的中介。

原始出处:

Clara Carpeggiani,et al. Stress Echocardiography Positivity Predicts Cancer Death
JAHA.2017. https://doi.org/10.1161/JAHA.117.007104

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    2017-12-14 zhaohui6731
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1969374, encodeId=452a19693e490, content=<a href='/topic/show?id=091d1002385e' target=_blank style='color:#2F92EE;'>#预测癌症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100238, encryptionId=091d1002385e, topicName=预测癌症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f9279, createdName=slcumt, createdTime=Sat Jul 21 08:01:00 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045347, encodeId=51f0204534e48, content=<a href='/topic/show?id=7e4de13990f' target=_blank style='color:#2F92EE;'>#癌症死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71399, encryptionId=7e4de13990f, topicName=癌症死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Tue May 22 03:01:00 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651026, encodeId=04ba16510266c, content=<a href='/topic/show?id=2aa35090181' target=_blank style='color:#2F92EE;'>#心动图#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50901, encryptionId=2aa35090181, topicName=心动图)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a7624121693, createdName=zhu_jun9845, createdTime=Sun Aug 26 13:01:00 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267648, encodeId=a84a126e648a2, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Dec 14 10:01:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445187, encodeId=9cf1144518ee6, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Dec 14 10:01:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268901, encodeId=10da2689018e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Tue Dec 12 19:13:03 CST 2017, time=2017-12-12, status=1, ipAttribution=)]
    2017-12-12 orangesking

    0