JAHA：脑卒中对认知的纵向影响！

2018-01-15 xing.T MedSci原创

由此可见，卒中与认知功能减退的风险增加有关，但认知下降并不是一个结局。与下降有关的因素，如社会人口状况、健康相关的合并症、卒中史和临床特征都可用于预测卒中后痴呆的未来风险。风险模型的方法可以识别需要及时干预的高风险患者，以降低或延缓脑卒中后认知障碍和痴呆的发病。

卒中与老年痴呆症的风险增加有关，然而，卒中对认知的影响已被发现具有可变性，例如卒中幸存者认知功能可以下降、保持稳定或恢复到基线。了解卒中后认知障碍的自然病史对干预有重要意义。近日，心血管疾病领域权威杂志JAHA上发表了一篇荟萃分析文章，这项系统回顾的目的是调查卒中幸存者的认知功能的纵向变化过程。

研究人员使用OvidSP检索了三个电子数据库（MEDLINE、EMBASE和PsycINFO），检索时间从数据库成立到2016年7月15日截止。卒中后认知评估超过两次的纵向研究被纳入分析。

研究人员总共检索到了5952篇文献，其中14篇纳入分析。卒中幸存者的认知评估分数有显著恶化趋势（8项研究）。认知稳定性（3项研究）和改善（3项研究）也有报道证实，尽管这些研究的随访时间往往更短。与认知损伤相关的变量包括年龄、种族、发病前的认知表现、抑郁症、卒中的部位和既往卒中史。ApoE基因* E4（载脂蛋白E的E4等位基因）等位基因状况与性别之间的相关性被混合在一起。

由此可见，卒中与认知功能减退的风险增加有关，但认知下降并不是一个结局。与下降有关的因素，如社会人口状况、健康相关的合并症、卒中史和临床特征都可用于预测卒中后痴呆的未来风险。风险模型的方法可以识别需要及时干预的高风险患者，以降低或延缓脑卒中后认知障碍和痴呆的发病。

原始出处：

Eugene YH Tang,et al. Longitudinal Effect of Stroke on Cognition: A Systematic Review.JAHA.2018.https://doi.org/10.1161/JAHA.117.006443

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2018-01-21 Ramsey

学习了.不错!

38 0
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2018-01-17 thlabcde

好资料学习了!

30 0
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2018-01-17 zhaohui6731

#AHA#

14 0
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2018-01-17 三生有幸9135

学习一下谢谢分享

24 0
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2018-01-16 天涯183

非常好的文章.学习了

38 0
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2018-01-15 邓启付

卒中患者认知和日常生活能力也会越来越差

43 0
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2018-01-15 changjiu

学习一下谢谢

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