内分泌科

订阅

MedSci主页 / 所有栏目 / 内分泌科

DIABETOLOGIA：儿童体重指数和成人糖尿病的轨迹研究

2019-04-04 不详 网络

儿童BMI糖尿病
关注

<span style="font-size:12.0pt;font-family:宋体;mso-ascii-font-family: Calibri;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:宋体;mso-fareast-theme-font: minor-fareast;mso-hansi-font-family:Ca

本研究的目的是描述儿童体重指数的纵向分布，并研究独立水平的儿童体重指数对成人2型糖尿病的影响。

纵向队列包括2449名成年人(1613名白人和836名黑人)，从童年(4-19岁)到成年(20-51岁)对他们的BMI测量了4到15次，并在成年时测量了空腹血糖。采用生长曲线参数及其一阶导数，以1年为间隔计算儿童各年龄点BMI的模型估计水平和线性斜率。

结果显示，BMI从童年到成年符合立方生长曲线；不同种族、性别间的线性和非线性曲线参数差异显著。体重指数显示了15年后的种族和性别差异。在种族-性别组中，高血糖者的BMI水平高于正常血糖者。在成人高血糖组中，BMI的线性和非线性斜率参数始终存在显著差异。在对混杂因素进行校正后，4-19岁儿童的BMI水平的OR为成人高血糖1.45-1.83 (p < 0.001)。10 ~ 19岁时BMI水平调整线性斜率与成人高血糖呈显著正相关(或1.17 ~ 1.50，均p < 0.01)。5 ~ 9岁儿童BMI线性斜率与成人高血糖的相关性不显著。这些关联的趋势在不同种族和性别群体中是一致的。

这些观察表明，儿童BMI轨迹对成人糖尿病有显著影响，与BMI水平无关。青春期是老年糖尿病发展的关键时期，对早期预防具有重要意义。

原始出处：

Tao Zhang, Jie Xu,Trajectories of childhood BMI and adult diabetes: the Bogalusa Heart Study

本文系梅斯医学（MedSci）原创编译整理，转载需授权！


版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1639063, encodeId=19a01639063d2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Apr 13 00:46:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761074, encodeId=a0121e61074b8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Jun 23 16:46:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364207, encodeId=e67c36420ee4, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqYPFHuMA3bhYQrHvycmum7IJoCsLK0FP6X56Eoj9PZAECDke8zLCKxZZvk9q7B6rZmPuFgN5YCfw/132, createdBy=f52d2514454, createdName=SCI我的梦, createdTime=Sat Apr 06 09:03:28 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042355, encodeId=59541042355c0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Apr 05 00:46:00 CST 2019, time=2019-04-05, status=1, ipAttribution=)]
    2019-04-13 ms9608593228839890

    #DIA#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1639063, encodeId=19a01639063d2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Apr 13 00:46:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761074, encodeId=a0121e61074b8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Jun 23 16:46:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364207, encodeId=e67c36420ee4, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqYPFHuMA3bhYQrHvycmum7IJoCsLK0FP6X56Eoj9PZAECDke8zLCKxZZvk9q7B6rZmPuFgN5YCfw/132, createdBy=f52d2514454, createdName=SCI我的梦, createdTime=Sat Apr 06 09:03:28 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042355, encodeId=59541042355c0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Apr 05 00:46:00 CST 2019, time=2019-04-05, status=1, ipAttribution=)]
    2019-06-23 ms5439512287675881

    #BET#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1639063, encodeId=19a01639063d2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Apr 13 00:46:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761074, encodeId=a0121e61074b8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Jun 23 16:46:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364207, encodeId=e67c36420ee4, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqYPFHuMA3bhYQrHvycmum7IJoCsLK0FP6X56Eoj9PZAECDke8zLCKxZZvk9q7B6rZmPuFgN5YCfw/132, createdBy=f52d2514454, createdName=SCI我的梦, createdTime=Sat Apr 06 09:03:28 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042355, encodeId=59541042355c0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Apr 05 00:46:00 CST 2019, time=2019-04-05, status=1, ipAttribution=)]
    2019-04-06 SCI我的梦

    谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1639063, encodeId=19a01639063d2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Apr 13 00:46:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761074, encodeId=a0121e61074b8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Jun 23 16:46:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364207, encodeId=e67c36420ee4, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqYPFHuMA3bhYQrHvycmum7IJoCsLK0FP6X56Eoj9PZAECDke8zLCKxZZvk9q7B6rZmPuFgN5YCfw/132, createdBy=f52d2514454, createdName=SCI我的梦, createdTime=Sat Apr 06 09:03:28 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042355, encodeId=59541042355c0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Apr 05 00:46:00 CST 2019, time=2019-04-05, status=1, ipAttribution=)]
    2019-04-05 misszhang

    谢谢MedSci提供最新的资讯

    0

相关资讯

Pediatr Allergy Immunol：舌下免疫治疗能够改变梯牧草过敏儿童的唾液lgA和全身免疫调控因子

舌下免疫治疗的免疫调控响应对过敏性儿童的全身和粘膜调控因子的影响仍旧大部分未知。最近，有研究人员在一个为期3年梯牧草花粉舌下免疫治疗的过敏性鼻炎儿童群体中，调查了相关的细胞因子和趋化因子水平以及lgA响应情况。研究发现，在3年的治疗后以及治疗结束2年后，GRAZAX®治疗的儿童表现出了显著更高的phl p1特异性唾液IgA和血清IgG4水平，以及显著更低的皮刺试验阳性率。另外，Th1相关的趋化因子

儿童急性中耳炎与合理用药

婴幼儿急性中耳炎是儿科的常见疾病，临床发病率仅此于感冒，也是感冒后极易引发的并发症。急性中耳炎宝宝常常表现为耳朵疼痛，啼哭不止，并经常用手抓耳朵，伴发热、拒绝吃奶等症状。如果伴有鼓膜穿孔，还可能见到脓性黏液分泌物流出耳外，患儿听力减退。

Environ Int：儿童哮喘和鼻炎与家庭潮湿相关接触相关性研究

在2010年和2012年之间，有研究人员对来自中国7个城市的40010名学龄前儿童的家庭环境与健康结果进行了观察性的研究。在研究中，他们调查了当前居住环境的6个潮湿相关的指标（可见的霉菌斑、可见潮湿污渍、潮湿衣物及/或床上用品、水渍、窗玻璃凝结和发霉气味）与早期居住环境的3个潮湿相关指标（可见的霉菌斑、窗玻璃凝结和发霉气味）与儿童哮喘和鼻炎之间的相关性。研究发现，在多水平的逻辑回归分析中，当前居住

DIABETOLOGIA：1989- 2013年25年间26个欧洲中心儿童1型糖尿病发病率趋势和周期性变化：多中心前瞻性登记研究

· 2019-04-03

-->

JAHA：儿童体重指数的变化与成年期静脉血栓栓塞的风险

由此可见，BMI持续高于平均水平的儿童在成年期患VTE的风险更高。虽然7-13岁的体重增加额外增加了VTE风险，但13岁时超重减轻会完全使升高的风险降至正常。

Otol Neurotol：儿童突发感官听力损失研究

最近，有研究人员调查了突发感官听力损失（SSNHL）儿童的临床特性、病因学、治疗结果和预后因素，目的是最终来指导儿科群体中SSNHL的临床诊断和治疗。研究包括了诊断为SSNHL的患者，时间为2011年11月到2017年12月。研究包括了25名SSNHL儿童患者和149名SSNHL成年患者。研究发现，SSNHL儿童患者中最近或者之前病毒感染率（81.8%）和空腹血糖水平（5.23+1.47mmol/