J Endod：血管内皮生长因子与骨形成蛋白2对人牙髓干细胞成骨/成牙本质分化的并用效果研究

2017-05-04 lishiting MedSci原创

这篇研究的目的是为了评估协同并用血管内皮生长因子（VEGF）与骨形成蛋白2（BMP-2）是否可以增强体外培养的人牙髓干细胞（DPSCs）的成骨/成牙本质分化。

这篇研究的目的是为了评估协同并用血管内皮生长因子（VEGF）与骨形成蛋白2（BMP-2）是否可以增强体外培养的人牙髓干细胞（DPSCs）的成骨/成牙本质分化。

成骨/成牙本质分化培养基（OM）或生长培养基体外培养DPSCs，并施加不同浓度的VEGF和/或BMP-2刺激21天。茜素红染色（ARS）观察细胞矿化形成情况。不同浓度的VEGF和BMP-2协同并用，向DPSCs施加刺激21天。实验分组：组1：OM；组2：OM+VEGF；组3：OM+BMP-2；组4：OM+VEGF+BMP-2（亚组：组4a：VEGF刺激最初的7天，组4b：BMP-2刺激最后的14天，组4c：VEGF+BMP-2刺激21天）。随后，细胞进行定量ARS分析，或收集细胞进行定量聚合酶链式反应，观察核心结合因子α1（CBFA1）、碱性磷酸酶（ALP）和牙本质基质蛋白1（DMP-1）的表达改变。

结果显示，在未进行OM培养下，VEGF和/或BMP-2均无法诱导DPSCs的矿化形成。与OM相比，OM+VEGF可以诱导更多的矿化形成(P < .05)，而不是OM+BMP-2。在共同施加刺激的分组中，OM+VEGF组和组4a的诱导矿化能力最强，要明显优于OM组或其他组(P < .05)。定量聚合酶链式反应结果显示，组2、3和4a的CBFA1、ALP和DMP-1表达水平要明显高于组4b和4c(P < .05)。而ALP的表达水平只有组4a明显高于OM组(P < .05)。另外，3种基因的表达在组2和组3之间未见明显差异(P > .05)。

结论：在矿化诱导早期施加VEGF刺激能够增强DPSCs的成骨/成牙本质分化，而不是持续向DPSCs施加VEGF和BMP-2的共同刺激。

原始出处：

Aksel H， Huang GT. Combined Effects of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 on Odonto/Osteogenic Differentiation of Human Dental Pulp Stem Cells In Vitro. J Endod. 2017 Apr 27. pii： S0099-2399(17)30151-6. doi： 10.1016/j.joen.2017.01.036.

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言

评论区 (8)

#插入话题

插入图片

[GetPortalCommentsPageByObjectIdResponse(id=1669575, encodeId=7d4616695e526, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Dec 06 02:05:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351601, encodeId=ad4a135160111, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441863, encodeId=33581441863c9, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517954, encodeId=f367151e9542d, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544877, encodeId=adea15448e7db, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597123, encodeId=fae5159e1232b, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193836, encodeId=425c1938364f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:33:47 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193794, encodeId=02ee193e94a7, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu May 04 19:10:23 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
2017-12-06 jxrzshh

#牙髓#

28 0
[GetPortalCommentsPageByObjectIdResponse(id=1669575, encodeId=7d4616695e526, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Dec 06 02:05:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351601, encodeId=ad4a135160111, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441863, encodeId=33581441863c9, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517954, encodeId=f367151e9542d, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544877, encodeId=adea15448e7db, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597123, encodeId=fae5159e1232b, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193836, encodeId=425c1938364f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:33:47 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193794, encodeId=02ee193e94a7, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu May 04 19:10:23 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
2017-05-06 zhaojie88

#成骨#

36 0
[GetPortalCommentsPageByObjectIdResponse(id=1669575, encodeId=7d4616695e526, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Dec 06 02:05:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351601, encodeId=ad4a135160111, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441863, encodeId=33581441863c9, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517954, encodeId=f367151e9542d, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544877, encodeId=adea15448e7db, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597123, encodeId=fae5159e1232b, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193836, encodeId=425c1938364f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:33:47 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193794, encodeId=02ee193e94a7, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu May 04 19:10:23 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
2017-05-06 ms8538335253054589

#牙本质#

36 0
[GetPortalCommentsPageByObjectIdResponse(id=1669575, encodeId=7d4616695e526, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Dec 06 02:05:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351601, encodeId=ad4a135160111, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441863, encodeId=33581441863c9, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517954, encodeId=f367151e9542d, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544877, encodeId=adea15448e7db, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597123, encodeId=fae5159e1232b, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193836, encodeId=425c1938364f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:33:47 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193794, encodeId=02ee193e94a7, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu May 04 19:10:23 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
2017-05-06 仁医06

#生长因子#

27 0
[GetPortalCommentsPageByObjectIdResponse(id=1669575, encodeId=7d4616695e526, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Dec 06 02:05:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351601, encodeId=ad4a135160111, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441863, encodeId=33581441863c9, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517954, encodeId=f367151e9542d, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544877, encodeId=adea15448e7db, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597123, encodeId=fae5159e1232b, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193836, encodeId=425c1938364f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:33:47 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193794, encodeId=02ee193e94a7, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu May 04 19:10:23 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
2017-05-06 ms6519009802973839

#牙髓干细胞#

26 0
[GetPortalCommentsPageByObjectIdResponse(id=1669575, encodeId=7d4616695e526, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Dec 06 02:05:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351601, encodeId=ad4a135160111, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441863, encodeId=33581441863c9, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517954, encodeId=f367151e9542d, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544877, encodeId=adea15448e7db, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597123, encodeId=fae5159e1232b, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193836, encodeId=425c1938364f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:33:47 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193794, encodeId=02ee193e94a7, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu May 04 19:10:23 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
2017-05-06 qilu_qi

#血管内皮生长因子#

29 0
[GetPortalCommentsPageByObjectIdResponse(id=1669575, encodeId=7d4616695e526, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Dec 06 02:05:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351601, encodeId=ad4a135160111, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441863, encodeId=33581441863c9, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517954, encodeId=f367151e9542d, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544877, encodeId=adea15448e7db, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597123, encodeId=fae5159e1232b, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193836, encodeId=425c1938364f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:33:47 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193794, encodeId=02ee193e94a7, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu May 04 19:10:23 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
2017-05-04 ayl3691

学习了

69 0
[GetPortalCommentsPageByObjectIdResponse(id=1669575, encodeId=7d4616695e526, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Wed Dec 06 02:05:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351601, encodeId=ad4a135160111, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441863, encodeId=33581441863c9, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517954, encodeId=f367151e9542d, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544877, encodeId=adea15448e7db, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67671, encryptionId=f5576e67147, topicName=牙髓干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=841913671773, createdName=ms6519009802973839, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597123, encodeId=fae5159e1232b, content=<a href='/topic/show?id=23be895453d' target=_blank style='color:#2F92EE;'>#血管内皮生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89545, encryptionId=23be895453d, topicName=血管内皮生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f2a18492798, createdName=qilu_qi, createdTime=Sat May 06 10:05:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193836, encodeId=425c1938364f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WialLm5LHWYz6x7b5eEhRkZQhWcia9KcYYyzWYqFu0xXaGG7KKGia6ZsYkfpAON6w39LKvSTH8MoDjORTsc3snVGQ/132, createdBy=e0fb1972964, createdName=ayl3691, createdTime=Thu May 04 22:33:47 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193794, encodeId=02ee193e94a7, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu May 04 19:10:23 CST 2017, time=2017-05-04, status=1, ipAttribution=)]
2017-05-04 三生有幸9135

学习一下谢谢分享

63 0

内科

外科

专科科室

热点

按科室浏览

临床工具

科研工具

其他工具

科研数智化

真实世界研究解决方案

数字化学术传播解决方案

其它

口腔科

J Endod：血管内皮生长因子与骨形成蛋白2对人牙髓干细胞成骨/成牙本质分化的并用效果研究

相关资讯

科室

工具

服务