Circulation:共享数据的可用性及其在心脏代谢临床试验中的应用

2017-12-11 佚名 国家循环

目前,患者水平临床试验数据的共享已被广泛认可。但是,人们对于如何将这些数据更广泛用于心脏代谢疾病仍知之甚少。AHA 2017科学年会上发布的一项最新研究评估了心脏代谢临床试验共享数据的可用性及其应用。

目前,患者水平临床试验数据的共享已被广泛认可。但是,人们对于如何将这些数据更广泛用于心脏代谢疾病仍知之甚少。AHA 2017科学年会上发布的一项最新研究评估了心脏代谢临床试验共享数据的可用性及其应用。

研究者布莱根妇女医院心血管中心的Muthiah Vaduganathan等对大型共享平台ClinicalStudyDataRequest.com收集的13家制药公司赞助完成的研究之患者水平数据进行分析。2013年1月~2017年5月,该平台共计涉及3374项临床试验的数据,其中537项(16%)是有关心脏代谢治疗的(1期、2期、2/3期、3期及4期临床试验的比例分别为36%、17%、1%、42%和4%)。这些研究共涉及74种治疗和398 925例患者,其中糖尿病高血压是研究的重点(所占比例分别为60%和15%)。上述研究从研究完成到数据可用的平均时间为79个月,截止2017年5月ClinicalStudyDataRequest.com共计收到318份提案,其中163份签署了数据共享协议,30份与心脏代谢治疗相关,涉及79项独特研究。大多数(96%)有关心脏代谢临床试验数据共享的数据申请者来自北美、西欧的学术中心。此外,大多数提案是为了进行二次假设,仅一个提案是对原创研究的主要假设进行再分析。迄今为止,在实现数据共享后平均19个月的时间里,已共计发现3篇同行评议文章。

上述结果提示,尽管ClinicalStudyDataRequest.com这一平台上已有超过500项心脏代谢临床实验的数据可供应用,但目前真正实现数据贡献的临床试验仅有15%(3/4期临床试验中这一比例为29%),基于这些共享数据分析所发表的文章则更少。

原始出处:
Muthiah Vaduganathan, et al. Use of an Open Access Multi-Sponsor Data Sharing Platform in Cardiology. Circulation. Nov 2017.

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#插入话题
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    2017-12-17 虈亣靌

    学习了.很好的话题.

    0

  2. 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    2017-12-16 飘飘爱

    很好

    0

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  4. 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channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29973, encryptionId=436d299e33d, topicName=共享)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec1e17938205, createdName=chendoc248, createdTime=Wed Dec 13 14:42:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268861, encodeId=592a268861da, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Dec 12 14:26:34 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268822, encodeId=22d426882242, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Dec 12 09:12:48 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268781, encodeId=d01f268e8103, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Dec 12 06:57:18 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268765, encodeId=7140268e65d9, content=谢谢学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:37:03 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268763, encodeId=0e78268e63b6, content=谢谢学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:36:46 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268753, encodeId=fb9e268e53eb, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-12-13 chendoc248
  5. 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level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:37:03 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268763, encodeId=0e78268e63b6, content=谢谢学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:36:46 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268753, encodeId=fb9e268e53eb, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-12-12 虈亣靌

    学习了.涨知识

    0

  6. 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level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:37:03 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268763, encodeId=0e78268e63b6, content=谢谢学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:36:46 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268753, encodeId=fb9e268e53eb, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Dec 12 05:43:52 CST 2017, time=2017-12-12, status=1, ipAttribution=)]
    2017-12-12 明月清辉

    学习了.谢谢分享

    0

  7. 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level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:37:03 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268763, encodeId=0e78268e63b6, content=谢谢学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:36:46 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268753, encodeId=fb9e268e53eb, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Dec 12 05:43:52 CST 2017, time=2017-12-12, status=1, ipAttribution=)]
    2017-12-12 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

  8. 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level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:37:03 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268763, encodeId=0e78268e63b6, content=谢谢学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:36:46 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268753, encodeId=fb9e268e53eb, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-12-12 Drhzm308

    谢谢学习了.

    0

  9. 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level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:37:03 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268763, encodeId=0e78268e63b6, content=谢谢学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:36:46 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268753, encodeId=fb9e268e53eb, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-12-12 Drhzm308

    谢谢学习了

    0

  10. 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level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:37:03 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268763, encodeId=0e78268e63b6, content=谢谢学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Dec 12 06:36:46 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268753, encodeId=fb9e268e53eb, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-12-12 yjs木玉

    好好好好好好好好

    0