Histol Histopathol:结外NK/T细胞淋巴瘤中TIM-3和LAG-3的表达分析

2017-09-23 AlexYang MedSci原创

最近,有研究人员调查了TIM-3和LAG-3在结外NK/T细胞淋巴瘤,鼻型(ENKTL)中表达的情况,并且评估了TIM-3和LAG-3在ENKTL中的临床和预后意义。研究包括了61个人类石蜡包埋样本,包括了41个ENKTL样本和20个鼻炎样本。研究人员还进行了免疫组化技术来检测TIM-3和LAG-3的表达,并且还分析了TIM-3和LAG-3的表达与ENKTL临床病理特性的关系。研究发现,TIM-3

最近,有研究人员调查了TIM-3和LAG-3在结外NK/T细胞淋巴瘤,鼻型(ENKTL)中表达的情况,并且评估了TIM-3和LAG-3在ENKTL中的临床和预后意义。研究包括了61个人类石蜡包埋样本,包括了41个ENKTL样本和20个鼻炎样本。研究人员还进行了免疫组化技术来检测TIM-3和LAG-3的表达,并且还分析了TIM-3和LAG-3的表达与ENKTL临床病理特性的关系。研究发现,TIM-3在ENKTL的95%样本中(39/41)表达,而在鼻炎样本中只有55%(11/20);LAG-3在95%(39/41)的ENKTL样本中表达,在鼻炎样本中只占45%(9/20)。TIM-3和LAG-3具有正相关关系。另外,TIM-3和LAG-3与ENKTL病人的年龄、性别、国际预后指数得分(IPI)、B症状、LDH水平、Ann Arbor分期和治疗方案没有显著的相关性。TIM-3的高表达、高IPI得分、提高的LDH水平和晚期Ann Arbor阶段与更差的无进展自由生存(PFS)相关。多变量COX回归模型表明了TIM-3的高表达是ENKTL病人PFS的独立预后因子。最后,研究人员指出,他们的发现

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    2018-05-19 yuanming17
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encryptionId=3dc91e454d3, topicName=TIM-3)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Tue Sep 04 23:38:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786188, encodeId=59c41e861887b, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Jun 12 11:38:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702430, encodeId=90a01e02430c4, content=<a href='/topic/show?id=ddc9e795159' target=_blank style='color:#2F92EE;'>#细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77951, encryptionId=ddc9e795159, topicName=细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=201630414353, createdName=marlenexl, createdTime=Tue Mar 20 02:38:00 CST 2018, time=2018-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249068, encodeId=0fac24906834, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Sep 30 09:23:32 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248567, encodeId=b8cd24856e7e, content=学习了获益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Sep 28 18:18:46 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372622, encodeId=822d13e262299, content=<a href='/topic/show?id=7d2d1802820' target=_blank style='color:#2F92EE;'>#T细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18028, encryptionId=7d2d1802820, topicName=T细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Sep 25 10:38:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247549, encodeId=eb2624e5497c, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Sep 25 09:42:43 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2018-09-04 cmsvly
  5. 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channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Sep 28 18:18:46 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372622, encodeId=822d13e262299, content=<a href='/topic/show?id=7d2d1802820' target=_blank style='color:#2F92EE;'>#T细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18028, encryptionId=7d2d1802820, topicName=T细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Sep 25 10:38:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), 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    2018-06-12 yb6560
  6. 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  7. 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channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Sep 28 18:18:46 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372622, encodeId=822d13e262299, content=<a href='/topic/show?id=7d2d1802820' target=_blank style='color:#2F92EE;'>#T细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18028, encryptionId=7d2d1802820, topicName=T细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Sep 25 10:38:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247549, encodeId=eb2624e5497c, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Sep 25 09:42:43 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-09-30 大爰

    学习并分享!!

    0

  8. 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    2017-09-28 虈亣靌

    学习了获益匪浅

    0

  9. 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  10. 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    2017-09-25 大爰

    学习了谢谢分享!!

    0