Neurology:精神兴奋剂对发作性睡病患者血压及内皮功能的影响!

2018-01-11 xing.T MedSci原创

由此可见,采用精神兴奋剂治疗的NT1患者的舒张压和舒张压高于未治疗患者,这表明其导致的心血管疾病长期风险增加需要进行仔细的随访和特异的管理。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在评估精神兴奋剂治疗对1型发作性睡病(NT1)患者24小时血压(BP)的影响。

研究人员监测了连续就诊的160例NT1患者24小时心率(HR)、血压(BP)和早晨血管内皮功能,这些受试者中有68例患者未接受治疗(男性41例,中位年龄为34.9岁),54例患者接受治疗(男性32例,平均年龄为40.9岁)以及38例患者在治疗前和治疗期间评估了两次(男性21例,中位年龄为32岁)。

接受治疗的NT1的患者与未接受治疗者相比,24小时、白天和夜间舒张压和HR值均较高。同样地,在治疗期间HR和24小时、白天收缩压在评估两次组也明显增加。兴奋剂和抗惊厥药物组合使用对BP有协同作用,在兴奋剂类别之间没有差异。基于24小时血压监测,58%接受治疗的患者和40.6%未接受治疗的患者被诊断高血压。在对年龄、性别和体重指数进行调整之后,在未接受治疗和接受治疗的患者中,REM睡眠百分比仍与24小时高血压相关。在治疗和未治疗的患者中内皮功能相当。

由此可见,采用精神兴奋剂治疗的NT1患者的舒张压和舒张压高于未治疗患者,这表明其导致的心血管疾病长期风险增加需要进行仔细的随访和特异的管理

原始出处:

Adriana Bosco,et al.Effect of psychostimulants on blood pressure profile and endothelial function in narcolepsy.Neurology. 2018. https://doi.org/10.1212/WNL.0000000000004911

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    2018-07-21 yinhl1978
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    2018-01-14 虈亣靌

    谢谢分享.学习了

    0

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    2018-01-11 sunfeifeiyang

    0