Nat Commun:高脂肪饮食能够通过重组代谢组和增强MYC来加速前列腺癌恶化

2019-10-21 AlexYang MedSci原创

与饱和脂肪酸消费的增加和肥胖相关的全身代谢的改变与前列腺癌恶化和死亡风险的增加有关,但是上述相关性的分子机制仍旧不清楚。最近,有研究人员通过一个前列腺癌小鼠模型阐释了高脂肪饮食(HFD)能够通过代谢的改变增强MYC转录,具体机制是代谢的改变能够促进MYC调控基因启动子区域组蛋白H4K20的低甲基化,从而增强MYC转录,进一步导致了细胞增殖的增加和肿瘤负担。在前列腺癌患者中,饱和脂肪摄入(SFI)同

与饱和脂肪酸消费的增加和肥胖相关的全身代谢的改变与前列腺癌恶化和死亡风险的增加有关,但是上述相关性的分子机制仍旧不清楚。

最近,有研究人员通过一个前列腺癌小鼠模型阐释了高脂肪饮食(HFD)能够通过代谢的改变增强MYC转录,具体机制是代谢的改变能够促进MYC调控基因启动子区域组蛋白H4K20的低甲基化,从而增强MYC转录,进一步导致了细胞增殖的增加和肿瘤负担。在前列腺癌患者中,饱和脂肪摄入(SFI)同样与MYC转录的增强相关。SFI诱导的MYC特征能够独立的预测前列腺癌的恶化和死亡。最后,从高脂肪饮食到低脂肪饮食的转变能够减弱MYC转录特征。

最后,研究人员指出,他们的发现表明了在原发性前列腺癌中,日常SFI能够通过诱导MYC过表达来导致肿瘤的恶化,也为改善饮食治疗方法奠定了基础。

原始出处:

David P. Labbé, Giorgia Zadra, Meng Yang et al. High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program. Nat Commun. 25 Sep 2019

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    2020-01-14 liye789132251
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    2019-12-22 liuli5079
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    2019-10-23 guihongzh
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    2019-10-23 pcw111
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    2019-10-21 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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    2019-10-21 明天jing

    代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。

    0

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