Am J Respir Crit Care:HIV感染者口腔微生物群改变与肺功能下降有关

2019-11-12 xing.T MedSci原创

由此可见,PWH口腔微生物群的改变与肺功能受损和全身性炎症有关。这些结果表明,口腔微生物组可作为HIV患者肺功能的生物标志物,其紊乱可能会导致COPD发病。

与HIV相关的慢性阻塞性肺疾病(COPD)发病机制研究较少。口腔微生物组会影响肺部微生物组,肠道菌群失调会影响肺部疾病。然而,尚未有研究探讨口腔和肠道微生物组与HIV感染者(PWH)COPD之间的关系。近日,呼吸内科以及重症医学领域权威杂志Am J Respir Crit Care上发表了一篇研究文章,研究人员评估了PWH的口腔和肠道微生物组变化与肺部疾病之间的相关性。

研究人员对来自多中心艾滋病队列研究的75名PWH和93名未感染HIV的男性进行了肺功能检查。对唾液和粪便中的细菌16S rRNA进行测序。研究人员使用非度量多维标度、排列的多元多元分析和线性判别分析并根据HIV和肺功能来分析社区。

口腔微生物组组成因HIV和吸烟状况而异。在肺功能异常的PWH中观察到口腔微生物群落的变化,其中韦荣球菌、链球菌和乳杆菌的相对丰度增加。未感染HIV的个体的口腔微生物组与肺功能之间无显著关联。肠道微生物组未发现与HIV状况或肺功能相关。

由此可见,PWH口腔微生物群的改变与肺功能受损和全身性炎症有关。这些结果表明,口腔微生物组可作为HIV感染者肺功能的生物标志物,其紊乱可能会导致COPD发病。 

原始出处:

Libing Yang,et al.Alterations in Oral Microbiota in HIV are Related to Decreased Pulmonary Function.AM J RESPIR CRIT CARE.2019.https://doi.org/10.1164/rccm.201905-1016OC           

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