感染

订阅

MedSci主页 / 所有栏目 / 感染

MJ:分子和免疫学分析间日疟复发

2017-06-21 MedSci MedSci原创

间日疟复发
关注

由间日疟原虫和卵形疟原虫的休眠体激活所引起的复发给疟疾的控制带来了严重的障碍。 伯氨喹作为一种单一的许可药物，可用于消除肝脏中的休眠体。迄今为止，关于间日疟原虫感染的研究仍很少。

由间日疟原虫和卵形疟原虫的休眠体激活所引起的复发给疟疾的控制带来了严重的障碍。 伯氨喹作为一种单一的许可药物，可用于消除肝脏中的休眠体。迄今为止，关于间日疟原虫感染的研究仍很少。

本研究基于两个基因（Pvmsp1F3和Pvcsp）和四个微卫星标记（MS3.27，MS3.502，MS6和MS8）的多态性区域，对12对经过伯氨喹治疗后复发的间日疟患者的样品进行测定。研究显示8个间日疟原虫群体在入院的复发样品中是同源的，在剩余的四个患者中是异源的。患者的CYP2D6基因型并没有表明伯氨喹的代谢不良。与同源性复发事件中的IgG3反应相比，原虫血症往往在异源群体中较高。对于所有样品中的十二个促炎细胞因子水平进行测定，与入院和复发事件中的同源相比，只有IL-6和IL-10在异源性患者中较高。

从有限数量确诊的复发患者中所获得数据反映了先前所观察到泰国间日疟原虫复发感染中存在数目较大的异源原虫群体。患者接受初次治疗的失败是由药物代谢不良所致的可能性较小，而很可能是由于在泰国存在对8-氨基喹啉敏感性差的间日疟原虫群体。

原始出处：

Sarunya ManeerattanasakPanita GosiSrivicha Krudsood,et.al. Molecular and immunological analyses of confirmed Plasmodium vivax relapse episodes.

本文系梅斯医学（MedSci）原创编译整理，转载需授权！


版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1889410, encodeId=d0271889410f0, content=<a href='/topic/show?id=f9fa290030a' target=_blank style='color:#2F92EE;'>#免疫学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29003, encryptionId=f9fa290030a, topicName=免疫学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Nov 23 04:59:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988127, encodeId=9290198812ecb, content=<a href='/topic/show?id=1b9f9e2582d' target=_blank style='color:#2F92EE;'>#间日疟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97258, encryptionId=1b9f9e2582d, topicName=间日疟)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Mar 12 04:59:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213739, encodeId=ce87213e3985, content=学习了，很好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Thu Jun 22 07:09:54 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213668, encodeId=d22821366885, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 22 00:37:39 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-11-23 xiaoyeshuang

    #免疫学#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1889410, encodeId=d0271889410f0, content=<a href='/topic/show?id=f9fa290030a' target=_blank style='color:#2F92EE;'>#免疫学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29003, encryptionId=f9fa290030a, topicName=免疫学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Nov 23 04:59:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988127, encodeId=9290198812ecb, content=<a href='/topic/show?id=1b9f9e2582d' target=_blank style='color:#2F92EE;'>#间日疟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97258, encryptionId=1b9f9e2582d, topicName=间日疟)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Mar 12 04:59:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213739, encodeId=ce87213e3985, content=学习了，很好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Thu Jun 22 07:09:54 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213668, encodeId=d22821366885, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 22 00:37:39 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2018-03-12 仁心济世

    #间日疟#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1889410, encodeId=d0271889410f0, content=<a href='/topic/show?id=f9fa290030a' target=_blank style='color:#2F92EE;'>#免疫学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29003, encryptionId=f9fa290030a, topicName=免疫学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Nov 23 04:59:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988127, encodeId=9290198812ecb, content=<a href='/topic/show?id=1b9f9e2582d' target=_blank style='color:#2F92EE;'>#间日疟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97258, encryptionId=1b9f9e2582d, topicName=间日疟)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Mar 12 04:59:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213739, encodeId=ce87213e3985, content=学习了，很好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Thu Jun 22 07:09:54 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213668, encodeId=d22821366885, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 22 00:37:39 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-22 stupidox

    学习了，很好。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1889410, encodeId=d0271889410f0, content=<a href='/topic/show?id=f9fa290030a' target=_blank style='color:#2F92EE;'>#免疫学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29003, encryptionId=f9fa290030a, topicName=免疫学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Nov 23 04:59:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988127, encodeId=9290198812ecb, content=<a href='/topic/show?id=1b9f9e2582d' target=_blank style='color:#2F92EE;'>#间日疟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97258, encryptionId=1b9f9e2582d, topicName=间日疟)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Mar 12 04:59:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213739, encodeId=ce87213e3985, content=学习了，很好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Thu Jun 22 07:09:54 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213668, encodeId=d22821366885, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 22 00:37:39 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-22 189****7206

    学习了受益匪浅

    0

相关资讯

Malar J：孕妇感染间日疟原虫会怎样？

疟疾是经按蚊叮咬或输入带疟原虫者的血液而感染疟原虫所引起的虫媒传染病。寄生于人体的疟原虫共有四种，即间日疟原虫，三日疟原虫，恶性疟原虫和卵形疟原虫。疟疾主要表 现为周期性规律发作，全身发冷、发热、多汗，长期多次发作后，可引起贫血和脾肿大。已有研究表明，怀孕期间女性体内恶性疟原虫诱发疟疾可能导致胎盘病变和宫内生长受限(IUGR)等不良妊娠结局。但是关于孕期间日疟原虫诱发疟疾的相关研究目前几乎还没有。