J Hepatol:2016-2030年间,中国、法国、德国、意大利、日本、西班牙、英国和美国等国家的NAFLD负担

2018-09-23 MedSci MedSci原创

NAFLD和NASH是一项巨大且日益严重的公共卫生问题,需要努力减轻疾病负担。如果肥胖和DM继续以当前和历史的速度增长,那么预测NAFLD和NASH的流行率将增加。NAFLD和NASH都是可逆的提高认识和诊断,通过饮食和锻炼可以帮助控制未来疾病负担的增长。

研究背景和目的:在全球,由非酒精性脂肪性肝病(NAFLD)和非酒精性脂肪性肝炎导致的肝硬化和肝癌,正逐渐增加。由于肥胖、糖尿病和代谢综合症等继续增加,预计疾病负担进一步增加。本研究的目的是依据现有的数据,采用Markov模型去预测NAFLD的疾病负担。

研究方法:本研究依据肥胖和2型糖尿病的数据,在8个国家采用模型评估NAFLD和NASH疾病进展。已发表的估计和专家共识用于建立模型和验证模型预测。

研究结果:如果肥胖和糖尿病在未来会趋于平稳,研究预测在2016至2030年间,NAFLD疾病病例将会中度增加 (0-30%);其中,由于城市化,中国NAFLD病例增长最高;由于人口减少,日本NAFLD病例增长最低。然而,与此同时,NASH患病率将增加15%-56%;由于人口老龄化/人口增加,肝癌和晚期肝病的发病率将增加一倍以上。

研究结论:NAFLD和NASH是一项巨大且日益严重的公共卫生问题,需要努力减轻疾病负担。如果肥胖和DM继续以当前和历史的速度增长,那么预测NAFLD和NASH的流行率将增加。NAFLD和NASH都是可逆的提高认识和诊断,通过饮食和锻炼可以帮助控制未来疾病负担的增长。

原始出处

Estes C, Anstee QM, Arias-Loste MT, et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030. J Hepatol, 2018, 69(4), 896-904.

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    2019-08-13 lvygwyt2781
  2. [GetPortalCommentsPageByObjectIdResponse(id=2083919, encodeId=bdd120839198d, content=<a href='/topic/show?id=d3b820e32c' target=_blank style='color:#2F92EE;'>#AFLD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2073, encryptionId=d3b820e32c, topicName=AFLD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Tue Aug 13 10:49:00 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350583, encodeId=315835058300, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be5d2470559, createdName=12437deam67暂无昵称, createdTime=Fri Oct 26 16:29:21 CST 2018, time=2018-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347442, encodeId=5a1834e442d9, content=学习了,谢谢作者分享/, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Sep 30 22:36:23 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294431, encodeId=19c2129443187, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Tue Sep 25 08:49:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385424, encodeId=ac951385424c7, content=<a href='/topic/show?id=c31c5322844' target=_blank style='color:#2F92EE;'>#意大利#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53228, encryptionId=c31c5322844, topicName=意大利)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Tue Sep 25 08:49:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394345, encodeId=43e913943458f, content=<a href='/topic/show?id=6fa7508342c' target=_blank style='color:#2F92EE;'>#德国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50834, encryptionId=6fa7508342c, topicName=德国)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Tue Sep 25 08:49:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399903, encodeId=714713999032f, content=<a href='/topic/show?id=51b56481e5c' target=_blank style='color:#2F92EE;'>#法国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64817, encryptionId=51b56481e5c, topicName=法国)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAEDER5XgbF1YHYrZAUzQRb28zMfZSQYO9TlxMY9GrSlIvElouBEHntsqmbAWtxHwdqqtGx0dCsw/0, createdBy=ed132239308, createdName=neurowu, createdTime=Tue Sep 25 08:49:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427240, encodeId=42f4142e24056, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Tue Sep 25 08:49:00 CST 2018, time=2018-09-25, status=1, ipAttribution=)]
    2018-10-26 12437deam67暂无昵称

    谢谢

    0

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    2018-09-30 1e145228m78(暂无匿称)

    学习了,谢谢作者分享/

    0

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    2018-09-25 neurowu
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    2018-09-25 gwc384

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