J Clin Periodontol: 全身炎症对牙周炎与血糖关系的分析

2018-05-20 MedSci MedSci原创

该横断面研究调查了牙周炎,全身炎症和血糖之间的关联。

该横断面研究调查了牙周炎,全身炎症和血糖之间的关联。

参与者被分为三组:正常血糖,空腹血糖异常(IFG)和糖尿病。多项Logistic回归用于检测牙周炎严重程度与血糖之间的关联,以调整潜在的混杂因素。对4种全身炎症标志物,C反应蛋白(CRP),白细胞计数(WBC),中性粒细胞淋巴细胞比率(NLR)和血小板淋巴细胞比率(PLR)进行调解分析。

结果:这项研究纳入2,036名39-66岁的参与者。重度牙周炎与IFG和糖尿病的相关性分别为1.6(95%可信区间[CI]:1.1-2.4,p = 0.023)和2.4(95%CI:1.3-4.5,p = 0.006)。 CRP,WBC和PLR均与牙周炎严重程度和血糖状态有关(p <.05)。相反,NLR与牙周炎严重程度(p <.05)相关,但与血糖状态无关(p> .05)。 CRP,WBC和PLR分别与严重牙周炎和糖尿病相关性为8%,13%和6%,与牙周炎-IFG也有相似的相关性。研究结果支持全身性炎症作为牙周炎与IFG或糖尿病之间关联的介体的作用。

原始出处:

Kitti Torrungruang, et al. Mediation analysis of systemic inflammation on the association between periodontitis and glycaemic status. Journal of Clinical Periodontology. 2018 May. doi:10.1111/jcpe.12884

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    2019-04-03 feather89
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    2018-05-22 liuyong2982
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    2018-05-20 有备才能无患

    参与者被分为三组:正常血糖.空腹血糖异常(IFG)和糖尿病.多项Logistic回归用于检测牙周炎严重程度与血糖之间的关联.以调整潜在的混杂因素.对4种全身炎症标志物.C反应蛋白(CRP).白细胞计数(WBC).中性粒细胞淋巴细胞比率(NLR)和血小板淋巴细胞比率(PLR)进行调解分析.

    0

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    2018-05-20 清风拂面

    谢谢分享学习

    0

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循环的CXCL10可能反映全身炎症,与急性失代偿、ACLF和严重门静脉高压症患者的并发症相关。CXCL10预测这些患者的生存率和CXCL10的减少可能被认为是一个好的预后因素。

J Periodontal Res:牙龈炎可能参与了系统性疾病的发病机制

菌血症,系统性炎症标记物与牙周及系统性疾病之间存在着某些联系,且有可能参与了这些疾病的发病机制。本研究旨在探究牙龈炎的发展过程中系统性炎性标记物以及菌血症的变化。研究纳入80名研究对象,根据性别、是否吸烟以及牙龈出血位点数,将其随机分成两组:对照组(n=40)和实验性牙龈炎组(n=40)。对照组每天刷牙两次,使用常规氟化钠护齿牙膏和普通手动牙刷,配合使用牙线两次/每天,漱口水(含氟化物抗龋成分)漱