Prostate Cancer P D:美国不同社会经济状态患者的积极监测或者观察等待治疗趋势研究

2019-10-22 AlexYang MedSci原创

预期的证据支持了积极监测/观察等待治疗(AS/WW)是低风险前列腺癌患者的有效治疗选择,并且能够避免潜在的治疗毒性。AS/WW过程需要常规的跟踪调查和患者的依从,但是关于患者经济社会状态(SES)情况对AS/WW治疗决定的影响仍旧未知。最近,有研究人员确定了是否AS/WW在不同的患者SES中是不同的。研究包括了50302名男性,研究发现,AS/WW的使用随着SES变好而增加(在低、中和高SES中分

预期的证据支持了积极监测/观察等待治疗(AS/WW)是低风险前列腺癌患者的有效治疗选择,并且能够避免潜在的治疗毒性。AS/WW过程需要常规的跟踪调查和患者的依从,但是关于患者经济社会状态(SES)情况对AS/WW治疗决定的影响仍旧未知。最近,有研究人员确定了是否AS/WW在不同的患者SES中是不同的。

研究包括了50302名男性,研究发现,AS/WW的使用随着SES变好而增加(在低、中和高SES中分别为24.6%、25.3%和30.5%)。从2010年到2015年,AS/WW的使用在低、中和高SES中的使用增加情况分别为从11.2到37.3%, 14.1到45.8%和17.6和46.4% (PTrends<0.001)。在2015年,AS/WW的使用可能性在中和高SES中相当(aOR 0.96, 95%CI: 0.83-1.11, P=0.55),但是在低和高SES比较中,AS/WW的使用在低SES中仍旧比例更低(aOR 0.73, 95% CI: 0.64-0.83, P<0.001)。

最后,研究人员指出,AS/WW的使用在低风险前列腺癌患者中由于SES的不同而不同。尽管AS/WW的使用从2010年到2015年使用有所增加,而在低SES中仍旧较少。SES对治疗的决定是有影响的,因此与低SES相关的因素也许是AS/WW使用的障碍,并且需要关注该情况从而减少低SES患者中不必要的治疗。

原始出处:

Santino S. Butler, Stacy Loeb, Alexander P. Cole et al. United States trends in active surveillance or watchful waiting across patient socioeconomic status from 2010 to 2015. Prostate Cancer P D. 07 Oct 2019

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1924495, encodeId=449e1924495c2, content=<a href='/topic/show?id=a7f2e3997c4' target=_blank style='color:#2F92EE;'>#社会经济#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73997, encryptionId=a7f2e3997c4, topicName=社会经济)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/D2FD7704B41C9E22364B1E54ABB223BB/100, createdBy=1df22500220, createdName=ms1260584454294838, createdTime=Mon Aug 24 11:06:00 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805568, encodeId=364e180556863, content=<a href='/topic/show?id=af59e83582d' target=_blank style='color:#2F92EE;'>#经济状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78358, encryptionId=af59e83582d, topicName=经济状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri May 08 15:06:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791588, encodeId=b0651e915889a, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Mon Jan 06 21:06:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953291, encodeId=beb4195329125, content=<a href='/topic/show?id=8dbae512483' target=_blank style='color:#2F92EE;'>#积极监测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75124, encryptionId=8dbae512483, topicName=积极监测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b70c362, createdName=jiadan198782, createdTime=Thu Apr 30 06:06:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364534, encodeId=970c1364534c1, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602203, encodeId=6c351602203d1, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616991, encodeId=8fa116169919e, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1924495, encodeId=449e1924495c2, content=<a href='/topic/show?id=a7f2e3997c4' target=_blank style='color:#2F92EE;'>#社会经济#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73997, encryptionId=a7f2e3997c4, topicName=社会经济)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/D2FD7704B41C9E22364B1E54ABB223BB/100, createdBy=1df22500220, createdName=ms1260584454294838, createdTime=Mon Aug 24 11:06:00 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805568, encodeId=364e180556863, content=<a href='/topic/show?id=af59e83582d' target=_blank style='color:#2F92EE;'>#经济状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78358, encryptionId=af59e83582d, topicName=经济状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri May 08 15:06:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791588, encodeId=b0651e915889a, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Mon Jan 06 21:06:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953291, encodeId=beb4195329125, content=<a href='/topic/show?id=8dbae512483' target=_blank style='color:#2F92EE;'>#积极监测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75124, encryptionId=8dbae512483, topicName=积极监测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b70c362, createdName=jiadan198782, createdTime=Thu Apr 30 06:06:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364534, encodeId=970c1364534c1, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602203, encodeId=6c351602203d1, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616991, encodeId=8fa116169919e, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1924495, encodeId=449e1924495c2, content=<a href='/topic/show?id=a7f2e3997c4' target=_blank style='color:#2F92EE;'>#社会经济#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73997, encryptionId=a7f2e3997c4, topicName=社会经济)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/D2FD7704B41C9E22364B1E54ABB223BB/100, createdBy=1df22500220, createdName=ms1260584454294838, createdTime=Mon Aug 24 11:06:00 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805568, encodeId=364e180556863, content=<a href='/topic/show?id=af59e83582d' target=_blank style='color:#2F92EE;'>#经济状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78358, encryptionId=af59e83582d, topicName=经济状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri May 08 15:06:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791588, encodeId=b0651e915889a, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Mon Jan 06 21:06:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953291, encodeId=beb4195329125, content=<a href='/topic/show?id=8dbae512483' target=_blank style='color:#2F92EE;'>#积极监测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75124, encryptionId=8dbae512483, topicName=积极监测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b70c362, createdName=jiadan198782, createdTime=Thu Apr 30 06:06:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364534, encodeId=970c1364534c1, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602203, encodeId=6c351602203d1, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616991, encodeId=8fa116169919e, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1924495, encodeId=449e1924495c2, content=<a href='/topic/show?id=a7f2e3997c4' target=_blank style='color:#2F92EE;'>#社会经济#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73997, encryptionId=a7f2e3997c4, topicName=社会经济)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/D2FD7704B41C9E22364B1E54ABB223BB/100, createdBy=1df22500220, createdName=ms1260584454294838, createdTime=Mon Aug 24 11:06:00 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805568, encodeId=364e180556863, content=<a href='/topic/show?id=af59e83582d' target=_blank style='color:#2F92EE;'>#经济状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78358, encryptionId=af59e83582d, topicName=经济状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri May 08 15:06:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791588, encodeId=b0651e915889a, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Mon Jan 06 21:06:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953291, encodeId=beb4195329125, content=<a href='/topic/show?id=8dbae512483' target=_blank style='color:#2F92EE;'>#积极监测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75124, encryptionId=8dbae512483, topicName=积极监测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b70c362, createdName=jiadan198782, createdTime=Thu Apr 30 06:06:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364534, encodeId=970c1364534c1, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602203, encodeId=6c351602203d1, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616991, encodeId=8fa116169919e, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1924495, encodeId=449e1924495c2, content=<a href='/topic/show?id=a7f2e3997c4' target=_blank style='color:#2F92EE;'>#社会经济#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73997, encryptionId=a7f2e3997c4, topicName=社会经济)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/D2FD7704B41C9E22364B1E54ABB223BB/100, createdBy=1df22500220, createdName=ms1260584454294838, createdTime=Mon Aug 24 11:06:00 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805568, encodeId=364e180556863, content=<a href='/topic/show?id=af59e83582d' target=_blank style='color:#2F92EE;'>#经济状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78358, encryptionId=af59e83582d, topicName=经济状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri May 08 15:06:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791588, encodeId=b0651e915889a, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Mon Jan 06 21:06:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953291, encodeId=beb4195329125, content=<a href='/topic/show?id=8dbae512483' target=_blank style='color:#2F92EE;'>#积极监测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75124, encryptionId=8dbae512483, topicName=积极监测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b70c362, createdName=jiadan198782, createdTime=Thu Apr 30 06:06:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364534, encodeId=970c1364534c1, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602203, encodeId=6c351602203d1, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616991, encodeId=8fa116169919e, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=)]
    2019-10-24 lsndxfj
  6. [GetPortalCommentsPageByObjectIdResponse(id=1924495, encodeId=449e1924495c2, content=<a href='/topic/show?id=a7f2e3997c4' target=_blank style='color:#2F92EE;'>#社会经济#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73997, encryptionId=a7f2e3997c4, topicName=社会经济)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/D2FD7704B41C9E22364B1E54ABB223BB/100, createdBy=1df22500220, createdName=ms1260584454294838, createdTime=Mon Aug 24 11:06:00 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805568, encodeId=364e180556863, content=<a href='/topic/show?id=af59e83582d' target=_blank style='color:#2F92EE;'>#经济状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78358, encryptionId=af59e83582d, topicName=经济状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri May 08 15:06:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791588, encodeId=b0651e915889a, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Mon Jan 06 21:06:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953291, encodeId=beb4195329125, content=<a href='/topic/show?id=8dbae512483' target=_blank style='color:#2F92EE;'>#积极监测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75124, encryptionId=8dbae512483, topicName=积极监测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b70c362, createdName=jiadan198782, createdTime=Thu Apr 30 06:06:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364534, encodeId=970c1364534c1, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602203, encodeId=6c351602203d1, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616991, encodeId=8fa116169919e, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=)]
    2019-10-24 sunylz
  7. [GetPortalCommentsPageByObjectIdResponse(id=1924495, encodeId=449e1924495c2, content=<a href='/topic/show?id=a7f2e3997c4' target=_blank style='color:#2F92EE;'>#社会经济#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73997, encryptionId=a7f2e3997c4, topicName=社会经济)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/D2FD7704B41C9E22364B1E54ABB223BB/100, createdBy=1df22500220, createdName=ms1260584454294838, createdTime=Mon Aug 24 11:06:00 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805568, encodeId=364e180556863, content=<a href='/topic/show?id=af59e83582d' target=_blank style='color:#2F92EE;'>#经济状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78358, encryptionId=af59e83582d, topicName=经济状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri May 08 15:06:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791588, encodeId=b0651e915889a, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Mon Jan 06 21:06:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953291, encodeId=beb4195329125, content=<a href='/topic/show?id=8dbae512483' target=_blank style='color:#2F92EE;'>#积极监测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75124, encryptionId=8dbae512483, topicName=积极监测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b70c362, createdName=jiadan198782, createdTime=Thu Apr 30 06:06:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364534, encodeId=970c1364534c1, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602203, encodeId=6c351602203d1, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616991, encodeId=8fa116169919e, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Thu Oct 24 13:06:00 CST 2019, time=2019-10-24, status=1, ipAttribution=)]

相关资讯

Nat Commun:高脂肪饮食能够通过重组代谢组和增强MYC来加速前列腺癌恶化

与饱和脂肪酸消费的增加和肥胖相关的全身代谢的改变与前列腺癌恶化和死亡风险的增加有关,但是上述相关性的分子机制仍旧不清楚。最近,有研究人员通过一个前列腺癌小鼠模型阐释了高脂肪饮食(HFD)能够通过代谢的改变增强MYC转录,具体机制是代谢的改变能够促进MYC调控基因启动子区域组蛋白H4K20的低甲基化,从而增强MYC转录,进一步导致了细胞增殖的增加和肿瘤负担。在前列腺癌患者中,饱和脂肪摄入(SFI)同

Cell Death & Disease:前列腺癌中靶向Wnt/EZH2/microRNA-708信号途径能够抑制神经纤维瘤分化

前列腺癌(PC)的去势抵抗性与PC腔细胞分化成为激素激素难治性神经内分泌(NE)细胞有关。然而,控制致死性NE前列腺癌(NEPC)的机制仍旧不清楚。最近,有研究人员调查了前列腺癌恶性肿瘤到NEPC转化过程中的机制。研究发现,microRNA miR-708参与了NE分化,并在NEPC细胞和肿瘤活检样本中下调。miR-708能够靶向Sestrin-3来抑制叉头转录因子(FOXO1)的磷酸化,从而导致

晚期前列腺癌新药研发竞争格局

前列腺癌是一种男性雄激素依赖型的肿瘤,雄激素会刺激前列腺癌细胞的生长,诱使疾病进展。转移性前列腺癌患者常用药物去势治疗(ADT),最初应答率能达80%-90%,但几乎所有患者都会在去势治疗后最终进展为转移性去势抵抗性前列腺癌(mCRPC)。

Sci Rep:亚洲前列腺癌患者中周围血栓栓塞性血管疾病与雄激素阻断治疗相关性分析

最近,有研究人员在前列腺癌(PCa)患者中调查了血栓栓塞的血管疾病在雄激素阻断治疗(ADT)后的风险情况。研究包括了24464名在2000-2008年新诊断为PCa的患者,且是通过纵向医疗保险数据库获得数据。所有的的PCa患者分成了2组:ADT组和非ADT组。ADT治疗的患者再分成手术去势组,化学去势组和单独抗雄激素组。研究人员通过依赖时间变量的多重Cox比例风险回归评估了肺栓塞(PE)、外周动脉

Cell Death & Disease:前列腺癌中PAX5能够诱导IDH1-AS1上调来促进肿瘤的生长

前列腺癌(PCa)是世界范围内影响男性健康的主要恶性肿瘤之一。长非编码RNAs(lncRNAs)是一类长的转录本,并且报道在恶性肿瘤中是必要的调控因子。IDH1反义RS1(IDH1-AS1)是一个lncRNA,并能与基因互作来调控瓦博格效应。然而,其在PCa致瘤中的作用和机制仍旧不清楚。最近,有研究人员探索了IDH1-AS1在PCa肿瘤生长中的作用。研究发现,IDH1-AS1的表达在PCa样本和细

Nat Commun:日本人群全基因组关联分析鉴定了12个新的前列腺癌易感位点

全基因组关联分析(GWAS)已经鉴定了大约170个与前列腺癌(PCa)风险相关的位点,但是其中的大多数是在欧洲人群中鉴定的。最近,有研究人员利用GWAS和复制研究在一个大的日本群体(9960个案例和83943个男性对照)中鉴定了与PCa风险相关的新的易感位点。研究总共鉴定出了12个新的PCa位点,包括rs1125927 (TMEM17,P=3.95×10-16), rs73862213 (GATA