Chest:非恶性胸腔积液在临床上可能有大用途!

2017-01-08 xing.T MedSci原创

在这项最大的前瞻性NMPE患者研究的结果表明那些继发于器官功能障碍的NMPE具有极高的1年死亡率。此外,双侧和渗出性胸腔积液是死亡率增加的一个指标。临床医生应该知道这些预后不良的特点,并指导疾病管理。

继发于非恶性疾病胸腔积液可以代表有意义的发病率和死亡率。这些非恶性胸腔积液(NMPE)在慢性充血性心力衰竭(CHF)患者中是很常见的,CHF是NMPE的主要原因。尽管如此,然而其死亡风险和影响它们因素的数据较为有限。近日,呼吸疾病领域权威期刊Chest上针对这一问题发表了一篇研究文章。

研究者选取了在2008年3月到2015年3月期间连续就诊于胸腔医疗机构的782例患者,这些患者都有未确诊的胸腔积液。研究者对356例NMPE患者进行了进一步分析。并且进行了胸腔积液生物化学、细胞学、胸部超声扫描和胸片检查。对有临床指征的患者进行了超声、CT扫描、放射引导下穿刺活检和胸腔镜检查。研究者对患者至少随访12个月,他们的最终诊断由2名呼吸病专家进行独立的审查。

在782例患者中,356名(46%)被诊断患有NMPE。这些患者的平均年龄为68岁(SD17),患者中69%为男性。心脏、肾脏和肝脏功能衰竭患者的1年死亡率分别为50%、46%和25%。双侧胸腔积液(风险比为3.55,95%可信区间为2.22-5.68)和渗出性积液(风险比为2.78,95%可信区间为1.81-4.28)与NMPE患者预后不良相关,并且1年死亡率分别为57%和43%。

由此可见,在这项最大的前瞻性NMPE患者研究的结果表明那些继发于器官功能障碍的NMPE具有极高的1年死亡率。此外,双侧和渗出性胸腔积液是死亡率增加的一个指标。临床医生应该知道这些预后不良的特点,并指导疾病管理。

原始出处:


Steven P. Walker, et al. Non-Malignant Pleural Effusions (NMPE): a prospective
study of 356 consecutive unselected patients
. Chest. 2016. 

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    2017-08-20 Smile2680
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    2017-01-09 虈亣靌

    学习了,分享了。

    0