Oral Oncol:新一代测序技术检测口腔鳞状细胞癌的可能癌变区域研究

2017-05-17 lishiting MedSci原创

局部复发和原发肿瘤的二次发展(SPT)是影响口腔鳞状细胞癌(OSCC)患者生存率的重要因素。这篇研究是为了评估研究者们提出的癌变区域理念:与原发性肿瘤相邻的正常组织存在癌前病变,可导致局部复发和SPTs发展。

局部复发和原发肿瘤的二次发展(SPT)是影响口腔鳞状细胞癌(OSCC)患者生存率的重要因素。这篇研究是为了评估研究者们提出的癌变区域理念:与原发性肿瘤相邻的正常组织存在癌前病变,可导致局部复发和SPTs发展。

为了验证是否存在癌变区域的理念,研究者们应用全外显子和靶向超深测序技术检测5个新鲜冻存的样本。样本来源于III级OSCC患者的3个肿瘤部位、转移的淋巴结和血液。最后,研究者们大约在1年半后收集经过福尔马林固定石蜡包埋的复发活检组织进行测序,组织样本的部位位于与之前相同的区域。

结果发现,测序证实存在126个体细胞突变。研究者们在复发活检组织中鉴定出24个突变体,其中有14个突变体与原发肿瘤相同。

结论:这些少量存在的相同突变体表明,它们要么代表原发肿瘤发展过程中非常早期的克隆,要么代表原发和复发肿瘤来源于同一个癌前区域。在2份例证中,临床复发都来源于同一个克隆,说明复发要么是通过相邻粘膜中突变的细胞迁移至癌变区域,要么是由剩余的肿瘤组织产生。

原始出处

Tabatabaeifar S, Larsen MJ, et al. Investigating a case of possible field cancerization in oral squamous cell carcinoma by the use of next-generation sequencing. Oral Oncol. 2017 May;68:74-80. doi: 10.1016/j.oraloncology.2017.03.018.

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    2018-03-31 minlingfeng
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    2017-12-04 小几洁
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    2017-05-19 axin014
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    2017-05-18 ylzr123

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

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