NEJM:Evacetrapib不能有效降低患者心血管事件风险

2017-05-18 zhangfan MedSci原创

Evacetrapib可显著改善患者脂蛋白生物指标但不能有效降低患者心血管事件风险

胆固醇酯转移蛋白抑制剂Evacetrapib可大幅提高高密度脂蛋白(HDL)胆固醇水平,减少低密度脂蛋白(LDL)胆固醇水平,提高细胞胆固醇流出能力。近日研究人员公布Evacetrapib对高危血管疾病患者主要心血管不良结局的试验结果。

研究招募了12092名患者,患者满足至少一项以下要求:1年内发生急性冠脉综合征、脑血管动脉粥样硬化性疾病或周围血管病变或糖尿病合并冠心病。患者随机接受130 mg Evacetrapib或安慰剂。主要终点是首次发生心血管疾病、心肌梗死卒中、冠状动脉血运重建或不稳定心绞痛住院死亡等复合终点事件。

在治疗3个月后,Evacetrapib组平均LDL-C下降31.1%vs安慰剂增加6.0%;Evacetrapib组平均HDL-C增加133.2%,而安慰剂增加1.6%。共发生1363起终点事件,临床研究提前终止。在26个月的试验期间,Evacetrapib组终点事件发生率为12.9%,安慰剂组为12.8%(风险比, 1.01; 95% CI, 0.91-1.11; P=0.91)

研究认为,Evacetrapib可显著改善患者脂蛋白生物指标但不能有效降低患者心血管事件风险。

原始出处:


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    2018-03-17 xue8602
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    2017-11-27 柳叶一刀
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    2017-10-15 仁者大医
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    2017-06-16 jyzxjiangqin

    关注有效降低患者心血管事件风险。

    0

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    2017-05-28 jyzxjiangqin

    心血管事件风险的因素。

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    2017-05-19 ylzr123

    认真学习,不断进步,把经验分享给同好。点赞了!

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