BMJ Open Diabetes Res Care:哪些因素会增加糖尿病患者的心血管并发症风险?

2016-10-05 Mechront 译 MedSci原创

根据一项回顾性分析结果显示:波多黎各人的2型糖尿病成年患者,男性、≥50岁、疾病控制不佳的患者,更有可能出现心血管并发症。 来自波多黎各糖尿病控制中心的Efrain Rodriguez-Vigil博士,和同事们对2075例1型糖尿病和2型糖尿病患者数据进行了研究分析,这些患者在2001年到2009年至少就诊两次内分泌学家(平均就诊次数为7.8)。 每次就诊都对患者进行身体检查,包括血压

根据一项回顾性分析结果显示:波多黎各人的2型糖尿病成年患者,男性、≥50岁、疾病控制不佳的患者,更有可能出现心血管并发症。

来自波多黎各糖尿病控制中心的Efrain Rodriguez-Vigil博士,和同事们对2075例1型糖尿病和2型糖尿病患者数据进行了研究分析,这些患者在2001年到2009年至少就诊两次内分泌学家(平均就诊次数为7.8)。

每次就诊都对患者进行身体检查,包括血压、体重指数等。评估患者的慢性糖尿病并发症的患病率,以及其他健康相关并发症。使用多因素回归分析,评估与自我报告的心血管并发症相关的因素。

校正BMI、脉压、高密度脂蛋白胆固醇后,研究人员发现,男性与女性相比,心血管并发症的可能性高出1.5倍(OR = 1.72; 95% CI, 1.21-2.45);糖尿病病程5年到15年的患者,与病程不到5年的患者相比,心血管并发症风险更高(OR = 1.55; 95% CI, 0.99-2.45),尤其是糖尿病持续时间超过15年的患者(OR = 2.52; 95% CI, 1.55-4.11)。

研究人员也观察到糖尿病患者更高的HbA1c水平与心血管并发症之间的“强关联”。

研究人员写道:虽然目前还不能设定阈值,但是我们发现,当HbA1c水平超过7%之后,每增加1个单位,心血管事件的风险增加21%。

调整性别、糖尿病病程、体重指数、血压、高密度脂蛋白胆固醇、糖化血红蛋白后的第二个模型分析中,微量蛋白尿患者与正常正常蛋白肾排泄患者相比,心血管并发症的风险高出2.5倍(OR = 2.46; 95% CI, 1.24-4.88)。

研究人员写道:糖尿病持续时间、糖化血红蛋白、 微量蛋白尿等是心血管并发症相关的强大风险因素。

原始出处:

Age, sex, metabolic control associated with CV complications in diabetes
.Healio.October 3, 2016

Rodriguez-Vigil E, et al. Correlation of global risk assessment with cardiovascular complications in patients with diabetes mellitus living in Puerto Rico
.BMJ Open Diabetes Res Care. 2016;doi:10.1136/bmjdrc-2016-000279.

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    2017-05-02 feather89
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    2017-06-10 丁鹏鹏
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    2017-02-05 gaoxiaoe
  4. 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  5. 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  6. 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  7. 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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

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