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Sci Rep：日本开发出恶性肿瘤干细胞检出技术

2017-04-29 佚名 科技部

恶性肿瘤干细胞
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日本东京医科齿科大学难治病研究所的科研人员利用老鼠进行试验，发现将癌细胞检测剂与铁离子吸附剂同时使用的话，不仅能够发现通常的癌细胞，而且连恶性肿瘤干细胞也可以容易地被发现。运用这一技术把肿瘤干细胞一个不剩地清除掉，将可防止癌症复发及转移。


日本东京医科齿科大学难治病研究所的科研人员利用老鼠进行试验，发现将癌细胞检测剂与铁离子吸附剂同时使用的话，不仅能够发现通常的癌细胞，而且连恶性肿瘤干细胞也可以容易地被发现。运用这一技术把肿瘤干细胞一个不剩地清除掉，将可防止癌症复发及转移。

在脑部肿瘤手术中，为防止正常组织被误切除，要使用 5 - 氨基乙酰丙酸(5-ALA)，使其在癌细胞内形成能发出荧光的原卟啉 PpIX。手术时用蓝光或紫光照射后，癌细胞即发出红光。

研究小组对老鼠脑癌细胞进行培养，并从中取出干细胞。利用这种干细胞对 PpIX 的荧光强度进行研究，发现较通常的癌细胞而言，这时发出的萤光强度要弱。研究人员想到，PpIX 与铁离子结合后会形成不发荧光的血红素，因而试着将治疗铁过剩病的去铁胺 (DFO)与 5 - 氨基乙酰丙酸组合起来使用。结果发现，铁离子放弃 PpIX 转而吸附于去铁胺，PpIX 不再变为血红素，其荧光强度不再变弱，肿瘤干细胞的检出率大幅度提高。

这一成果发表在 2 月 7 日的英国科学杂志《SCIENTIFIC REPORTS》上。

原始出处：

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-05-02 王国安

    学习了，科技再发展癌症攻克就不远了。

    0

  2. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-05-01 chentianping

    #日本#

    0

  3. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-05-01 林3301

    日本的医学还是发展在前沿

    0

  4. 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01 11:52:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192371, encodeId=a88f1923e120, content=日本的医学还是发展在前沿, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Mon May 01 07:09:33 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192280, encodeId=0a31192280b0, content=学习了，收获不小。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/27/136abcae2f8e58d33f28258f76f49b4f.jpg, createdBy=7e701980206, createdName=王国安, createdTime=Sun Apr 30 23:13:19 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192271, encodeId=01261922e122, content=收货多多, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ8X1yLOVj8WPicl2Fu38UJyue9g5yUbZYs8LBhr8juq58bkLYbZ7ic8fmlEUHXgAic73qLqVNnkXwrj/0, createdBy=8ebc2052195, createdName=大家, createdTime=Sun Apr 30 22:46:12 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192123, encodeId=895719212383, content=学习了，谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 王国安

    学习了，收获不小。

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 大家

    收货多多

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 一个尘埃

    学习了，谢谢分享。

    0

  7. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eotHc7cjrVcIHD9L2n3LzcQo1WSYledtExBOM76QRXV0FrtWOsoLNA9xaJmBjsBFwPvC7fNarGfAg/132, createdBy=531e1939570, createdName=一个尘埃, createdTime=Sun Apr 30 10:42:16 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192108, encodeId=9eb819210856, content=感谢分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun Apr 30 09:58:11 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192071, encodeId=50791920e1dc, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Apr 30 08:11:29 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192037, encodeId=0ded19203e3d, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun Apr 30 07:16:29 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192031, encodeId=f16019203172, content=学习过了！！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 laymankey

    感谢分享一下！

    0

  8. 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01 11:52:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192371, encodeId=a88f1923e120, content=日本的医学还是发展在前沿, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Mon May 01 07:09:33 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192280, encodeId=0a31192280b0, content=学习了，收获不小。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/27/136abcae2f8e58d33f28258f76f49b4f.jpg, createdBy=7e701980206, createdName=王国安, createdTime=Sun Apr 30 23:13:19 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192271, encodeId=01261922e122, content=收货多多, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ8X1yLOVj8WPicl2Fu38UJyue9g5yUbZYs8LBhr8juq58bkLYbZ7ic8fmlEUHXgAic73qLqVNnkXwrj/0, createdBy=8ebc2052195, createdName=大家, createdTime=Sun Apr 30 22:46:12 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192123, encodeId=895719212383, content=学习了，谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eotHc7cjrVcIHD9L2n3LzcQo1WSYledtExBOM76QRXV0FrtWOsoLNA9xaJmBjsBFwPvC7fNarGfAg/132, createdBy=531e1939570, createdName=一个尘埃, createdTime=Sun Apr 30 10:42:16 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192108, encodeId=9eb819210856, content=感谢分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun Apr 30 09:58:11 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192071, encodeId=50791920e1dc, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Apr 30 08:11:29 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192037, encodeId=0ded19203e3d, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sun Apr 30 07:16:29 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192031, encodeId=f16019203172, content=学习过了！！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 刘煜

    学习了谢谢分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=192665, encodeId=bcab192665c9, content=学习了，科技再发展癌症攻克就不远了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/27/136abcae2f8e58d33f28258f76f49b4f.jpg, createdBy=7e701980206, createdName=王国安, createdTime=Tue May 02 00:47:55 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294317, encodeId=5a32129431e74, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Mon May 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eotHc7cjrVcIHD9L2n3LzcQo1WSYledtExBOM76QRXV0FrtWOsoLNA9xaJmBjsBFwPvC7fNarGfAg/132, createdBy=531e1939570, createdName=一个尘埃, createdTime=Sun Apr 30 10:42:16 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192108, encodeId=9eb819210856, content=感谢分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun Apr 30 09:58:11 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192071, encodeId=50791920e1dc, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 医艺依意

    学习了，谢谢分享

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Apr 30 07:03:46 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 明天会更好！

    学习过了！！！！！！

    0

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