JCEM:糖尿病会增加原发性醛固酮增多症患者心脑血管风险和肾脏并发症

2020-04-15 MedSci原创 MedSci原创

该研究首次证明了DM是PA患者CCV事件和肾脏并发症的独立危险因素。除了针对PA的具体治疗外,应考虑对DM的治疗。

原发性醛固酮增多症(PA)患者糖尿病(DM)的患病率高于原发性高血压患者和一般人群。虽然DM是心脏脑血管(CCV)疾病和肾脏并发症的常见危险因素,但其对PA的影响尚未得到证实。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在明确PA患者合并DM对CCV事件风险和肾脏并发症进展的影响。

该研究为多中心横断面研究,在2006年1月至2016年10月期间,研究人员从从JPAS/JRAS日本PA登记处招募了CCV事件和DM数据可用的PA患者(n=2524)。通过logistic和线性回归分析将DM组与非DM组之间的CCV事件和肾并发症进行了比较。

DM显著增加了CCV事件(OR为1.59、95%CI为1.05-2.41)和蛋白尿(OR为2.25、95%CI为1.5-3.16)的比值比。并且DM与eGFR下降(β=0.05,p=0.02)相关。

由此可见,该研究首次证明了DM是PA患者CCV事件和肾脏并发症的独立危险因素。除了针对PA的具体治疗外,应考虑对DM的治疗。

原始出处:

Aya Saiki, et al.Diabetes mellitus itself increases cardio-cerebrovascular risk and renal complications in primary aldosteronism.J Clin Endocrinol Metab.2020.https://doi.org/10.1210/clinem/dgaa177

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    2020-09-14 achengzhao
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createdName=cmsvly, createdTime=Fri Apr 17 06:03:43 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043081, encodeId=18f31043081a7, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Apr 15 18:03:43 CST 2020, time=2020-04-15, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2080076, encodeId=658b20800e634, content=<a href='/topic/show?id=5efa956449d' target=_blank style='color:#2F92EE;'>#醛固酮增多症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95644, encryptionId=5efa956449d, topicName=醛固酮增多症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7b6284, createdName=FukaiBao, createdTime=Sun Jan 17 14:03:43 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1846879, encodeId=f31718468e9a3, content=<a href='/topic/show?id=d3a33e0306d' target=_blank style='color:#2F92EE;'>#原发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37030, encryptionId=d3a33e0306d, topicName=原发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, 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target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Dec 08 05:03:43 CST 2020, time=2020-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027085, encodeId=b032202e08524, content=<a href='/topic/show?id=292e51e2182' target=_blank style='color:#2F92EE;'>#心脑血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51721, encryptionId=292e51e2182, topicName=心脑血管风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Wed Feb 10 09:03:43 CST 2021, time=2021-02-10, status=1, ipAttribution=), 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  6. 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target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Dec 08 05:03:43 CST 2020, time=2020-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027085, encodeId=b032202e08524, content=<a href='/topic/show?id=292e51e2182' target=_blank style='color:#2F92EE;'>#心脑血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51721, encryptionId=292e51e2182, topicName=心脑血管风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Wed Feb 10 09:03:43 CST 2021, time=2021-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758233, encodeId=4a111e58233ce, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed May 20 18:03:43 CST 2020, time=2020-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379247, encodeId=e71d13e924786, content=<a href='/topic/show?id=ac549564240' target=_blank style='color:#2F92EE;'>#醛固酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95642, encryptionId=ac549564240, topicName=醛固酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Fri Apr 17 06:03:43 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043081, encodeId=18f31043081a7, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Apr 15 18:03:43 CST 2020, time=2020-04-15, status=1, ipAttribution=)]
    2020-12-08 smallant2015
  7. 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  8. 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createdName=cmsvly, createdTime=Fri Apr 17 06:03:43 CST 2020, time=2020-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043081, encodeId=18f31043081a7, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Apr 15 18:03:43 CST 2020, time=2020-04-15, status=1, ipAttribution=)]
    2020-05-20 丁鹏鹏
  9. 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    2020-04-17 cmsvly
  10. 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    2020-04-15 misszhang

    谢谢MedSci提供最新的资讯

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