Blood:在应激性红细胞生成过程中,硒蛋白可调控应激性红系祖细胞和脾脏微环境。

2018-04-04 MedSci MedSci原创

中心点:硒蛋白,特别是SelenoW,对应激性红系祖细胞扩增和成熟至关重要。巨噬细胞需要硒蛋白来维持红细胞生成壁龛的能力。摘要:微量元素硒(Se)通过作为第21种氨基酸硒化半胱氨酸(Sec)加入硒蛋白在氧化还调控中发挥关键作用。因为硒缺乏似乎是慢性炎性疾病相关性贫血的一个共因子,研究人员推断硒蛋白可能有助于红细胞生成,从而缓解贫血,称为应激性红细胞生成。现有研究人员发现硒缺陷导致硒蛋白缺失或Sec

中心点:

硒蛋白,特别是SelenoW,对应激性红系祖细胞扩增和成熟至关重要。

巨噬细胞需要硒蛋白来维持红细胞生成壁龛的能力。

摘要:

微量元素硒(Se)通过作为第21种氨基酸硒化半胱氨酸(Sec)加入硒蛋白在氧化还调控中发挥关键作用。因为硒缺乏似乎是慢性炎性疾病相关性贫血的一个共因子,研究人员推断硒蛋白可能有助于红细胞生成,从而缓解贫血,称为应激性红细胞生成。

现有研究人员发现硒缺陷导致硒蛋白缺失或Sec tRNA(tRNA[Sec])基因(Trsp)突变可从两个阶段严重损害应激性红细胞生成。早期应激性红系祖细胞不能扩张及分化成BFU-Es;晚期红系祖细胞表现为成熟障碍,可影响原红细胞(ProEs)转化成嗜碱性红细胞(BasoEs)。上述缺陷在一定程度上是由于硒蛋白W丢失导致;在Se缺陷的有核红细胞中,硒蛋白W在转录水平和蛋白水平表达水平均下降。骨髓细胞SelenoW突变可明显减少应激性BFU-E克隆的扩增,该结果反映了Trsp突变或Se缺陷所导致的表型。

与此相似的是,小鼠有核红细胞(G1E)的SelenoW突变可导致终末分化缺陷。除了红系缺陷,Se缺乏小鼠的脾脏内红髓巨核细胞减少、幼红细胞岛(EBI)巨噬细胞发育不良。

总而言之,上述数据提示,在急性贫血恢复期,硒蛋白,像红系壁龛一样,在应激性红系祖细胞的扩张和发育过程中发挥关键作用。

原始出处:

Chang Liao,et al.Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis.Blood  2018  :blood-2017-08-800607;  doi: https://doi.org/10.1182/blood-2017-08-800607

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    2018-04-04 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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