Sci Transl Med:中美科学家找到加速皮肤伤口愈合新方法

2018-03-16 周舟 新华网

一个中国和美国科研人员组成的团队14日报告说,他们从牙龈快速愈合的能力中得到启发,找到一种新的促进皮肤伤口愈合的方法。

一个中国和美国科研人员组成的团队14日报告说,他们从牙龈快速愈合的能力中得到启发,找到一种新的促进皮肤伤口愈合的方法。

相关论文发表在最新一期美国《科学·转化医学》杂志上。论文第一作者、美国宾夕法尼亚大学访问学者、中国北京大学口腔医学院的寇晓星对新华社记者说:“相比皮肤而言,口腔牙龈及粘膜的伤口愈合能力更强,且愈合后几乎没有瘢痕,但科学家对其背后的原因一直不太清楚。”

研究人员利用小鼠牙龈和皮肤上的间质干细胞展开的研究发现,受伤时,牙龈结缔组织干细胞会释放出比皮肤组织干细胞更多的白细胞介素1受体拮抗剂。这种物质可以通过抑制白细胞介素1介导的炎症反应,促进伤口愈合。

研究人员向小鼠注射用于治疗类风湿关节炎的白细胞介素1受体拮抗剂药物——阿那白滞素。结果显示,与普通小鼠相比,给药小鼠的伤口愈合显着加快。

糖尿病患者的伤口通常较难愈合。此次研究发现,患有糖尿病的小鼠,给药后其伤口同样会加速愈合。

但是干细胞能够治疗的疾病远远不止如此,研究发现,干细胞对于组织再生、身体免疫调节、新陈代谢都具有很大的优势。干细胞技术作为医学技术的重大发现,其潜力是无法估量的。所以,安全有效储存干细胞是对健康的投资。

原始出处:

Xiaoxing Kou,et al.The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing.Sci Transl Med.14 Mar 2018:Vol. 10, Issue 432, eaai8524

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    2018-06-14 bsmagic9140
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    2018-03-17 虈亣靌

    学习谢谢分享!

    0