Eur Radiol:CT灌注在评价胃癌影像学表现与组织学分型相关性的价值

2017-08-06 shaosai MedSci原创

胃癌根据组织学分类可以分为普通类型、特殊类型laurten's分型。普通的胃癌包括低分化腺癌、管状腺癌、印戒细胞癌、粘液腺癌和乳头状腺癌。。进展期胃癌按组织分型为乳头状腺癌、管状腺癌、未分化癌、低分化癌、鳞癌、腺癌、类癌、粘液细胞癌和粘膜腺癌。本研究为了评价CT灌注参数与胃癌组织学亚分型的相关性,并将结果发表在Eur Radiol上。

胃癌根据组织学分类可以分为普通类型、特殊类型laurten's分型。普通的胃癌包括低分化腺癌、管状腺癌、印戒细胞癌、粘液腺癌和乳头状腺癌。。进展期胃癌按组织分型为乳头状腺癌、管状腺癌、未分化癌、低分化癌、鳞癌、腺癌、类癌、粘液细胞癌和粘膜腺癌。本研究为了评价CT灌注参数与胃癌组织学亚分型的相关性,并将结果发表在Eur Radiol上。

本研究共纳入了46例术前行灌注CT(PCT)和根治性胃切除术的患者。分析PCT数据并由两位放射科医生独立评价并利用Kruskal-Wallis、Mann-Whitney U 检验和ROC分析比较各组织亚型间的差异性。利用组内相关系数(ICC)分析观察者间的一致性。

结果为,观察者间的一致性为中等-较好(ICC=0.585-0.678)。严重黏连的胃癌(PCC)的表面渗透值要明显高于其他类型(47.3 ml/100 g/min in PCC vs 26.5 ml/100 g/min in non-PCC,P<0.001)。PCC的平均通过时间(MTT)同样也比non-PCC的要长(13.0 s in PCC vs 10.3 s in non-PCC, P=0.032)。表面渗透性(P<0.001)和MTT (P=0.015)诊断PCC的曲线下面积为分别为0.891、0.697。

本研究表明,PCT中的灌注参数可以在胃癌患者中应用。因为PCC类型的表面渗透性和MTT值要明显高于non-PCC。因此,其可被用来在胃癌术前通过影像学来鉴别PCC类型的胃癌。

原始出处:

Lee DH, Kim SH, Joo I,et al. CT Perfusion evaluation of gastric cancer: correlation with histologic type. Eur Radiol. 2017.DOI: 10.1007/s00330-017-4979-5

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    2017-08-08 huagfeg
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    2017-08-08 1e0f8808m18(暂无匿称)

    学习了,好文章。

    0

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    2017-08-08 Drhzm308

    好的,学习了

    0

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    2017-08-07 1dec70a1m36(暂无匿称)

    分享了

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231014, encodeId=fd0223101422, content=本研究表明,PCT中的灌注参数可以在胃癌患者中应用。因为PCC类型的表面渗透性和MTT值要明显高于non-PCC。因此,其可被用来在胃癌术前通过影像学来鉴别PCC类型的胃癌。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Mon Aug 07 09:30:43 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231009, encodeId=1242231009de, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Mon Aug 07 09:16:52 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-07 天涯183

    非常好的文章,学习了,很受益

    0

  8. 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createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Mon Aug 07 09:16:52 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-07 清风拂面

    谢谢分享,学习了

    0

  9. 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    2017-08-07 Julie W

    本研究表明,PCT中的灌注参数可以在胃癌患者中应用。因为PCC类型的表面渗透性和MTT值要明显高于non-PCC。因此,其可被用来在胃癌术前通过影像学来鉴别PCC类型的胃癌。

    0

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createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Mon Aug 07 09:16:52 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-07 Y—xianghai

    学习了新知识

    0

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发表在美国癌症研究学会(American Association for Cancer Research)官方期刊Clinical Cancer Research上的一篇文章称,胃癌的四种分子分型有助于预测生存预后及患者的化疗效果,因此可能有望进一步精确指导治疗方案的制定。 德克萨斯大学MD安德森肿瘤中心癌症医学部系统生物学副教授Lee博士介绍道,胃癌大部分都会行手术治疗,其次行化疗。不过,这些

胃炎到胃癌仅4步,这样做阻断癌变!

近5年来,我国19~35岁青年人的胃癌发病率比30年前翻了一番,胃癌防治已经成为社会广泛关注的健康焦点。据医学统计数字显示,中国肠胃病患者有1.2亿,每年新增40万胃癌患者,占世界胃癌发病人数的42%。然而,胃癌不是由正常细胞迅速转变成癌细胞,从最开始的胃炎演变到最后的胃癌,是一个循序渐进的过程。胃炎到胃癌有四步Correa序列提出:从胃炎到胃癌有四步演变过程:慢性浅表性胃炎↓慢性萎缩性胃炎↓

J Cell Physiol:多吃番茄可抵抗胃癌的发生

胃癌是一种弥漫性和侵袭性的肿瘤,其死亡率在全世界高居榜首。胃癌发生的易感因素是E-cadherin基因突变、幽门螺杆菌感染和食用过多含盐和烟熏的食物,而新鲜水果和蔬菜的摄入量却很低。在这里,研究人员分析了意大利南部的两种番茄品种(San Marzano和Corbarino)中的总脂溶性提取物对体外胃癌模型(YCC-1,YCC-2和 YCC-3细胞株,侵袭性不同)的影响。结果显示,这两个品种的番茄都

胃病胃癌为什么会“传染”?我国幽门螺旋杆菌感染率已达59%

根据今年国际胃癌大会的报告,我国每年新增胃癌病例68万例,占全球发病总数的一半左右。 其中,最小的发病人群已低至25岁,40岁之后的胃癌发病率将增加1倍,其中男性发病率增长尤为显着。

Oncotarget:lincRNA-p21有作为胃癌潜在生物标志物和重要治疗靶点的潜力

lincRNA-p21,即长基因非编码RNA-p21,被称为p53直接转录靶,已发现其在几种人类实体瘤中下调。

Oncotarget:HADH表达下降通过激活Akt信号通路促进胃癌发展

胃癌的扩散和转移途径有直接浸润、血行转移、腹膜种植转移以及淋巴转移,其中淋巴转移是胃癌的主要转移途径,进展期胃癌的淋巴转移率高达70%左右,早期胃癌也可有淋巴转移。