JACC:高龄患者动脉粥样硬化性心脏病风险评估新体系

2018-05-31 MedSci MedSci原创

目前的指南推荐使用混合队列方程式(PCE)来评估患者10年的动脉粥样硬化性心血管疾病(CVD)发生风险,但这种评估体系有诸多缺点且并不适合年龄>79岁的老年患者。本研究的目的旨在评估将生物标志物加入PCE评估体系中是否能提高对老年患者短时间内的CVD风险的预测能力。本研究纳入了社区研究中的4760名(年龄为75.4 ± 5.1岁)无心血管疾病包括心衰的研究对象,并将N-末端B型利钠肽、高敏心脏肌钙

目前的指南推荐使用混合队列方程式(PCE)来评估患者10年的动脉粥样硬化性心血管疾病(CVD)发生风险,但这种评估体系有诸多缺点且并不适合年龄>79岁的老年患者。本研究的目的旨在评估将生物标志物加入PCE评估体系中是否能提高对老年患者短时间内的CVD风险的预测能力。

本研究纳入了社区研究中的4760名(年龄为75.4 ± 5.1岁)无心血管疾病包括心衰的研究对象,并将N-末端B型利钠肽、高敏心脏肌钙蛋白T和高敏C反应蛋白加入PCE评估体系,对研究对象进行动脉粥样硬化性心血管疾病发生风险进行评估。经过平均4年时间的随访,心衰是最主要的CVD事件(n = 193 vs. 118 冠心病和81 例卒中事件),与传统的PCE相比,每种生物标志物均能提高其预测能力,预测能力提高最大是3种标志物联合加入PCE评估体系中。

研究结果显示,对于高龄患者,将生物标志位加入到传统动脉粥样硬化性心血管疾病风险评估体系中能提高短时间内的预测能力。

原始出处:

Anum S et al.Short-Term Global Cardiovascular Disease Risk Prediction in Older Adults.JACC.2018 Jun.

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    2018-11-30 hbwxf
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time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320290, encodeId=9c83320290a0, content=好东西值得学习借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Thu May 31 13:58:44 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1854047, encodeId=c9c8185404e06, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Fri Nov 30 09:56:00 CST 2018, time=2018-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804103, encodeId=8ca518041030a, content=<a href='/topic/show?id=d1b2e630123' target=_blank style='color:#2F92EE;'>#粥样硬化性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76301, encryptionId=d1b2e630123, topicName=粥样硬化性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Jul 16 05:56:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045955, encodeId=91c4204595573, content=<a href='/topic/show?id=1f1410283499' target=_blank style='color:#2F92EE;'>#高龄患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102834, encryptionId=1f1410283499, topicName=高龄患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Mon Feb 04 01:56:00 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944531, encodeId=e1b71944531b9, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, 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time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320290, encodeId=9c83320290a0, content=好东西值得学习借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Thu May 31 13:58:44 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
  6. 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encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Tue Oct 23 14:56:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325849, encodeId=98341325849da, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Jun 02 03:56:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416072, encodeId=651414160e2d3, content=<a href='/topic/show?id=99fb1028231b' target=_blank style='color:#2F92EE;'>#高龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102823, encryptionId=99fb1028231b, topicName=高龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307c3130149, createdName=xlysu, createdTime=Sat Jun 02 03:56:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496311, encodeId=30081496311eb, content=<a href='/topic/show?id=43b6e358710' target=_blank style='color:#2F92EE;'>#硬化性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73587, encryptionId=43b6e358710, topicName=硬化性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8119265602, createdName=Smile2683, createdTime=Sat Jun 02 03:56:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559722, encodeId=8a311559e2214, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Sat Jun 02 03:56:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565731, encodeId=33af1565e3115, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Sat Jun 02 03:56:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320290, encodeId=9c83320290a0, content=好东西值得学习借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Thu May 31 13:58:44 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
    2018-06-02 xlysu
  7. 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  8. 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    2018-05-31 医者仁心5538

    好东西值得学习借鉴

    0

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