Stroke:无房颤的肥厚型心肌病发生栓塞的危险因素——高龄、左心房扩大

2016-05-31 phylis 译 MedSci原创

背景:卒中和全身性栓塞事件是肥厚性心肌病(HCM)的并发症,这些并发症在伴有心房颤动(AF)患者中更常见。但是,房颤的诊断有时是很困难的,它可能是亚临床无症状的阵发性发作或首次发作的房颤,都可能导致栓塞事件。研究者调查HCM患者栓塞事件的发生率,并且评估无房颤记录患者发生卒中或全身性栓塞的危险因素。方法:该研究纳入了1980到2010年,593例临床诊断为HCM的患者(诊断时的年龄,51±15.6

背景:卒中和全身性栓塞事件是肥厚型心肌病(HCM)的并发症,这些并发症在伴有房颤(AF)患者中更常见。但是,房颤的诊断有时是很困难的,它可能是亚临床无症状的阵发性发作或首次发作的房颤,都可能导致栓塞事件。研究者调查HCM患者栓塞事件的发生率,并且评估无房颤记录患者发生卒中或全身性栓塞的危险因素。

方法:该研究纳入了1980到2010年,593例临床诊断为HCM的患者(诊断时的年龄,51±15.6岁)。

结果:平均随访时间为10.7±7.5年,68(11.5%)例发生了卒中和栓塞事件。事件发生前,29(42.6%)患者已发生AF。在发生卒中和栓塞事件时,5例(7.4%)是首次记录发生房颤,10例(14.7%)是事件发生后记录发生房颤。在无房颤记录的431患者中(39例发生事件和392未发生事件),校正性别和与HCM相关的典型的预测标志物后,诊断时高龄、左心房内径≥48mm是栓塞事件的独立危险因素。

结论:HCM患者脑卒中和栓塞事件的发生率为每年1%,栓塞事件发生前,一半以上的患者无房颤记录。高龄和左心房扩大是无记录房颤患者发生血栓事件可能的危险因素。

原始出处:

Haruki S, Minami Y, Hagiwara N. Stroke and Embolic Events in Hypertrophic Cardiomyopathy: Risk Stratification in Patients Without Atrial Fibrillation. Stroke. 2016 Apr.


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1659694, encodeId=fceb165969474, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Tue Apr 11 22:01:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416038, encodeId=fe7e141603800, content=<a href='/topic/show?id=99fb1028231b' target=_blank style='color:#2F92EE;'>#高龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102823, encryptionId=99fb1028231b, topicName=高龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307c3130149, createdName=xlysu, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622235, encodeId=88a31622235b7, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626815, encodeId=c6d2162681551, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
    2017-04-11 ylz8411
  2. [GetPortalCommentsPageByObjectIdResponse(id=1659694, encodeId=fceb165969474, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Tue Apr 11 22:01:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416038, encodeId=fe7e141603800, content=<a href='/topic/show?id=99fb1028231b' target=_blank style='color:#2F92EE;'>#高龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102823, encryptionId=99fb1028231b, topicName=高龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307c3130149, createdName=xlysu, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622235, encodeId=88a31622235b7, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626815, encodeId=c6d2162681551, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
    2016-06-02 xlysu
  3. [GetPortalCommentsPageByObjectIdResponse(id=1659694, encodeId=fceb165969474, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Tue Apr 11 22:01:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416038, encodeId=fe7e141603800, content=<a href='/topic/show?id=99fb1028231b' target=_blank style='color:#2F92EE;'>#高龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102823, encryptionId=99fb1028231b, topicName=高龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307c3130149, createdName=xlysu, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622235, encodeId=88a31622235b7, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626815, encodeId=c6d2162681551, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1659694, encodeId=fceb165969474, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Tue Apr 11 22:01:00 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416038, encodeId=fe7e141603800, content=<a href='/topic/show?id=99fb1028231b' target=_blank style='color:#2F92EE;'>#高龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102823, encryptionId=99fb1028231b, topicName=高龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307c3130149, createdName=xlysu, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622235, encodeId=88a31622235b7, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626815, encodeId=c6d2162681551, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Thu Jun 02 07:01:00 CST 2016, time=2016-06-02, status=1, ipAttribution=)]
    2016-06-02 sodoo

相关资讯

Am J Cardiol:NT-proBN对肥厚型心肌病患者具有预测价值

意大利一项研究表明,在肥厚型心肌病患者中,血浆N-端脑利钠肽前体(NT-proBNP)为死亡和心衰相关性事件的有效独立预测因素。论文7月22日在线发表于《美国心脏病学杂志》(Am J Cardiol)。 此项研究共纳入183例稳定性肥厚型心肌病门诊患者(年龄50±17岁,男性64%),并在测定NT-proBNP后进行了3.9 ± 2.8随访。主要终点为心血

2014欧洲心脏病学会五大指南亮点

在2014年欧洲心脏病学会(ESC)年会上,新发布的五大指南亮点颇多,备受瞩目。现邀请专家撰文,告诉医生们应重点了解哪些内容。 2014ESC/ESA 非心脏手术心血管评估和治疗指南 新版指南指出,术前应对患者围术期心血管风险进行系统的个体化评估,内容包括评估手术本身引起的心血管风险及不同手术方式之间的心血管风险差异,评估患者当前心血管状态等。建议根据评估结果采取相应的预

Am J Cardiol:hs-cTnT联合BNP可用于心肌纤维化检测

  日本一项研究表明,在肥厚型心肌病患者中,高敏心脏肌钙蛋白T(hs-cTnT)和脑利钠肽(BNP)联合可用于检测心肌纤维化。论文于6月10日在线发表于《美国心脏病学杂志》(Am J Cardiol)。   此项研究共纳入53例肥厚型心肌病患者,其中23例患者伴有延迟钆增强。评估血清肌红蛋白、心肌肌球蛋白轻链I、hs-cTnT、肌酸激酶MB同工酶水平和血浆BNP水平与延迟钆增

Heart:阵发性房颤HCM患者易出现运动障碍

美国一项研究表明,在肥厚型心肌病(HCM)患者中,阵发性房颤与运动障碍具有相关性。论文12月10日在线发表于《心脏》(Heart)。 房颤是HCM最常见的心律失常。此项研究共纳入265例HCM患者,并对其实施了心肺试验和呼出气分析。采集基线人口统计数据、病史和静息超声心动图。通过病历和基线心电图确认房颤诊断。阵发性房颤患者在接受心肺试验时为窦性心律。以峰值VO2<20 mL/kg/mi

JACC:了解血流模式--早期筛查心肌病的新技术

心脏病有时并不比癌症可爱。肥厚型心肌病或扩张型心肌病在发病早期往往没有任何症状,但真到发现它们时往往较晚,预后较差,以至于大多数患者连5年的活头都没有,因此如何早发现很重要。最近从美国传了一个好消息,美工程师应用一种新颖的超声技术发现了心室内环形涡流对心室舒张功能的影响,从而使得在人群中筛查这两种疾病成为可能。而这种探测方法比磁共振(MRI)扫描更为“物美价廉”。 左心室是否增大,室壁是否增厚,

Stroke:无房颤记录的肥厚型心肌病患者发生栓塞的危险因素是什么?

卒中和全身栓塞事件是肥厚型心肌病(HCM)的并发症,这些并发症在伴随心房颤动(AF)的患者中更常见。AF的诊断有时是困难的,但是,它有可能是亚临床无症状的阵发性发作或者是之前没有房颤记录的患者首次AF发作可能导致的栓塞事件。研究人员调查了HCM患者栓塞事件的发生率,并评估了没有记录AF的患者发生这些事件的风险因素。该研究纳入了从1980年至2010年的593例临床诊断为HCM的患者(诊断时年龄,5