Crit Care Med：脓毒症的生存改善与线粒体钙摄取减少有关！

2017-04-17 MedSci MedSci原创

近期，一项发表在杂志Crit Care Med上的研究旨在评估脓毒症期间的预后，心脏线粒体钙摄取变化与心脏生物能量状态之间的关系。此项研究的对象为雄性成年Wistar大鼠。通过腹腔注射粪便诱导大鼠脓毒症。假手术的动物作为对照组。使用共聚焦显微镜研究24小时败血症后分离的心肌细胞的功能和生物能量参数。使用电子显微镜评估线粒体和肌质网中的结构变化。通过超声心动图评估心脏对多巴酚丁胺的功能反应。此项研究

近期，一项发表在杂志Crit Care Med上的研究旨在评估脓毒症期间的预后，心脏线粒体钙摄取变化与心脏生物能量状态之间的关系。

此项研究的对象为雄性成年Wistar大鼠。通过腹腔注射粪便诱导大鼠脓毒症。假手术的动物作为对照组。使用共聚焦显微镜研究24小时败血症后分离的心肌细胞的功能和生物能量参数。使用电子显微镜评估线粒体和肌质网中的结构变化。通过超声心动图评估心脏对多巴酚丁胺的功能反应。

此项研究结果显示：24小时的时候测得的主动脉血流速度峰值可以很好的鉴别72小时存活率（0.84±0.1；p = 0.03），24小时的体外实验中可以鉴定出具有良好预后的脓毒症动物。

具有良好预后的动物测量实验显示：1）起搏后线粒体钙含量和烟酰胺腺嘌呤二核苷酸荧光的增加幅度较小，2）电子显微镜下线粒体和肌浆网之间的距离增加，3）烟酰胺腺嘌呤二核苷酸氧化还原电位和三磷酸腺苷/二磷酸腺苷在起搏后未能达到新的稳态，表明能源供需匹配受损。在体内，良好的预后动物在中风体积和动能方面显示出对于多巴酚丁胺的钝化的反应。

此项研究表明：在更高能量需求的情况下，线粒体钙摄取可能构成适应性细胞反应，其以降低氧化能力的代价赋予对败血症的生存优势。

原始出处：
Pinto BB, Dyson A, et al. Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand. Crit Care Med. 2017 Apr 13. doi: 10.1097/CCM.0000000000002448.

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2017-04-21 tofsw

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2017-04-19 ms3994565386320060

#Med#

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2017-04-19 stupidox

阅读了谢谢分享

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createdBy=74221626377, createdName=tofsw, createdTime=Tue Apr 18 07:40:56 CST 2017, time=2017-04-18, status=1, ipAttribution=)]
2017-04-19 jin321

每天学习

37 0
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createdBy=74221626377, createdName=tofsw, createdTime=Tue Apr 18 07:40:56 CST 2017, time=2017-04-18, status=1, ipAttribution=)]
2017-04-18 吴教授

学习了

51 0
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2017-04-18 jiangwei200908

内容还不错，总有值得学习的地方

35 0
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2017-04-18 daiyaozu

学习了，不错

25 0
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2017-04-18 shaosai

好好学习，涨知识

18 0
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2017-04-18 龙胆草

学习了，谢谢分享

22 0
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2017-04-18 tofsw

学习了谢谢分享

23 0