长期腹泻 胃肠疾病还是另有“凶手”?

2017-07-24 曾昭耆 刘凤奎 曾昭耆 顾复生 专家临床笔录丛书.内科分册

患者,女,50岁。患者3个月来无明显诱因出现大便次数增多,每天2~3次逐渐增加到7~8次。多次查大便常规及培养均未见异常,腹部B超、CT、纤维结肠镜检查结果未见异常,化验肝肾功能也正常,诊断为慢性结肠炎、肠易激综合征,曾给予诺氟沙星、小檗碱(黄连素)、镇静药等多种药物治疗,均未见明显效果而入院。那么,该患者到底是何疾病?患者,女性,50岁,因腹泻3个月入院。患者3个月来无明显诱因出现大便次数增多,

患者,女,50岁。患者3个月来无明显诱因出现大便次数增多,每天2~3次逐渐增加到7~8次。多次查大便常规及培养均未见异常,腹部B超、CT、纤维结肠镜检查结果未见异常,化验肝肾功能也正常,诊断为慢性结肠炎、肠易激综合征,曾给予诺氟沙星、小檗碱(黄连素)、镇静药等多种药物治疗,均未见明显效果而入院。那么,该患者到底是何疾病?

患者,女性,50岁,因腹泻3个月入院。患者3个月来无明显诱因出现大便次数增多,每天2~3次逐渐增加到7~8次,为稀软便,无脓血及黏液,无腹痛及发热,食欲尚可,体重逐渐下降,3个月内减少5~6kg,自觉疲乏无力,头晕、心悸、失眠,多次到医院就诊。多次查大便常规及培养均未见异常,腹部B超、CT、纤维结肠镜检查结果未见异常,化验肝肾功能也正常,诊断为慢性结肠炎、肠易激综合征,曾给予诺氟沙星、小檗碱(黄连素)、镇静药等多种药物治疗,均未见明显效果而入院。

入院查体 一般情况尚好,消瘦,体重45kg,体温37.5℃,脉搏110次/分,呼吸24次/分,血压140/90mmHg,甲状腺不大,无震颤及血管杂音,巩膜不黄,全身皮肤无黄染、皮疹及出血点,全身浅表淋巴结不大,心率110次/分,律齐,各瓣膜区未闻杂音,两肺叩诊清音,未闻干湿啰音,无胸膜摩擦音,腹平软,无压痛,肝脾未及,肠鸣音正常,无腹水征。脊柱四肢无畸形,关节无红肿,神经系统检查未见异常。

辅助检查 血常规:Hb 100g/L,白细胞5.7 ×109/L,血小板150 ×109/L,尿常规正常,便常规:黄色软便,无脓血和黏液,镜检未见红、白细胞,大便培养阴性,胸片未见异常,心电图正常,腹部B超:肝、胆、胰、脾、肾未见异常,腹透未见异常。肝功能:血清胆红素5.1μmol,ALT 30U/L,AST 25U/L,血清总蛋白70g/L,白蛋白40g/L,球蛋白30g/L,肾功能正常。在触诊腹部时发现腹主动脉搏动明显增强而且脉率很快,此时,医生想到甲状腺功能亢进(甲亢)的可能,即做了甲状腺功能检查,结果TT 3、TT 4明显升高,最后诊断为甲状腺功能亢进症。给予丙基硫氧嘧啶治疗,两周后腹泻明显减轻,出院后继续按甲亢治疗。

误诊原因及教训

1﹒对以腹泻为突出表现的患者,除考虑胃肠方面的疾病以外,应想到全身性的一些疾病也可引起腹泻,如糖尿病、甲亢等,要详细询问病史,全面地进行体格检查。

2﹒患者虽不发热但心率一直较快,在门诊多次检查未给予重视,门诊病历中未对心脏情况做过描述。追问病史,患者半年来一直有心悸感,心率加快、脉搏洪大是甲亢的一个突出表现,应给予注意。

3﹒肠易激综合征的特征是虽长期腹泻伴有头晕、心悸、无力、失眠等,但病人全身情况好,不会有明显的消瘦,与该患者体重明显下降而且心率快是不符合的。

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    2017-10-13 damiao93

    学习了.谢谢分享

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    2017-07-30 大爰

    学习了谢谢分享!!

    0

  4. 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  5. 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    2017-07-26 雅文博武

    学习了先进的技术水平

    0

  6. 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    2017-07-26 flysky120

    学习一下知识

    0

  7. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRqicU7xBKdcEdwOZagicwjFSrx7JGp1GoPauQaYyupQ32Ced0jUAAqbia9f3PnhVk3KGt8wfibKIHXNb/0, createdBy=ea5c2063247, createdName=传说中的大哥, createdTime=Tue Jul 25 08:17:35 CST 2017, time=2017-07-25, status=1, ipAttribution=)]
    2017-07-25 1e10c84am36(暂无匿称)

    文章很好,谢分享

    0

  8. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRqicU7xBKdcEdwOZagicwjFSrx7JGp1GoPauQaYyupQ32Ced0jUAAqbia9f3PnhVk3KGt8wfibKIHXNb/0, createdBy=ea5c2063247, createdName=传说中的大哥, createdTime=Tue Jul 25 08:17:35 CST 2017, time=2017-07-25, status=1, ipAttribution=)]
    2017-07-25 往日如昨

    学习了谢谢分享

    0

  9. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRqicU7xBKdcEdwOZagicwjFSrx7JGp1GoPauQaYyupQ32Ced0jUAAqbia9f3PnhVk3KGt8wfibKIHXNb/0, createdBy=ea5c2063247, createdName=传说中的大哥, createdTime=Tue Jul 25 08:17:35 CST 2017, time=2017-07-25, status=1, ipAttribution=)]
    2017-07-25 damiao93

    学习了,谢谢

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue Jul 25 16:49:41 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226124, encodeId=f32d226124db, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCkPCv9CVFBmWOibyBArQwSeQLxvxz9OaumlaSUZjfCWTxbXduhuG2xCJUPs1nB9nd4gxZknH7IZj/0, createdBy=52281985209, createdName=damiao93, createdTime=Tue Jul 25 09:57:40 CST 2017, time=2017-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=226093, encodeId=e62c22609346, content=这个例子听说过, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRqicU7xBKdcEdwOZagicwjFSrx7JGp1GoPauQaYyupQ32Ced0jUAAqbia9f3PnhVk3KGt8wfibKIHXNb/0, createdBy=ea5c2063247, createdName=传说中的大哥, createdTime=Tue Jul 25 08:17:35 CST 2017, time=2017-07-25, status=1, ipAttribution=)]
    2017-07-25 传说中的大哥

    这个例子听说过

    0

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