2018长城会(GW-ICC):李南方:从OSAS与CVD的紧密联系看ICSD-3中OSAS诊断标准的更新

2017-10-20 佚名 国际循环

阻塞性睡眠呼吸暂停综合征(OSAS)与高血压等心血管疾病(CVD)密切相关。2015年美国睡眠医学会更新的《国际睡眠障碍(ICSD-3)分类指南》对OSAS的定义除涉及睡眠本身及监测到的症状外,与CVD密切联系起来。在本届GW-ICC 2017上,新疆自治区人民医院的李南方教授从OSAS与CVD的紧密联系对ICSD-3中OSAS诊断标准的更新作了专题解析,并强调关注CVD合并OSAS患者的必要性。

阻塞性睡眠呼吸暂停综合征(OSAS)与高血压等心血管疾病(CVD)密切相关。2015年美国睡眠医学会更新的《国际睡眠障碍(ICSD-3)分类指南》对OSAS的定义除涉及睡眠本身及监测到的症状外,与CVD密切联系起来。在本届GW-ICC 2017上,新疆自治区人民医院的李南方教授从OSAS与CVD的紧密联系对ICSD-3中OSAS诊断标准的更新作了专题解析,并强调关注CVD合并OSAS患者的必要性。

OSAS与CVD的相关性

多项调查研究显示,OSAS是高血压糖尿病、心律失常、心房颤动、心力衰竭、冠心病及缺血性脑血管病等CVD的重要危险因素。进一步研究发现,OSAS可通过多种病理生理学机制(交感激活、代谢紊乱、左心房扩大、内分泌紊乱、系统性炎症及高凝状态等)导致相关CVD的发病(图1)。



图1. OSAS与CVD相关的机制

ICSD-3有关OSAS的定义

之前,美国睡眠医学会主要依据睡眠本身和监测到的症状来对OSAS进行定义。既往指南认为,在7小时睡眠中,若每小时监测到5个或5个以上呼吸紊乱事件,加上A(无明确原因的白天嗜睡)或B(夜间窒息或喘气、反复觉醒、精神不能恢复的睡眠、白天疲乏、注意力集中困难中的两个或两个以上症状)则可诊断为OSAS。

在新一版国际睡眠障碍分类指南中,将睡眠障碍分为失眠、睡眠相关呼吸障碍、中枢性过眠症、失眠伴发症及睡眠相关的运动障碍五大类,而OSAS属睡眠相关呼吸障碍的一种。其对OSAS的定义也不再单纯依靠睡眠本身及监测到的症状来进行,而是将其与心血管事件密切联系起来(图2)。根据最新标准,只要患者被诊断为高血压、冠心病、卒中、心功能不全、心房颤动或2型糖尿病,若传统多导睡眠监测(PSG)或便携式呼吸睡眠监测设备(OCST)监测到每小时睡眠5次以上的阻塞性或混合性呼吸暂停、低通气或努力呼吸相关的觉醒,即可诊断为OSAS;若监测到每小时15次以上的呼吸事件,也可将其纳入OSAS的诊断。因此,临床实践中对于CVD患者,临床医生应格外关注和重视OSAS,以期尽早给予其临床干预并最大程度改善疾病预后。



图2. 国际睡眠障碍分类第三版对成人OSAS的诊断标准

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    2017-10-28 jiyangfei
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    2017-10-22 bioon3
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    2017-10-22 zhs3884
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    2017-10-22 chenwq12
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    2017-10-20 1e0f8808m18(暂无匿称)

    阻塞性睡眠呼吸暂停综合征是心血管病独立危险因素.

    0

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