IBD: 焦虑程度可预测炎症性肠病的不良结果

2019-07-06 不详 MedSci原创

患有炎症性肠病(IBD)的患者具有更高的精神疾病,但尚不清楚合并精神疾病的患者是否具有较高的预后不良风险。本项研究的目的是确定与没有焦虑和/或抑郁的IBD患者相比,患有IBD且患有焦虑和/或抑郁症的患者是否更可能具有较差的预后。

背景和目的
患有炎症性肠病(IBD)的患者具有更高的精神疾病,但尚不清楚合并精神疾病的患者是否具有较高的预后不良风险。本项研究的目的是确定与没有焦虑和/或抑郁的IBD患者相比,患有IBD且患有焦虑和/或抑郁症的患者是否更可能具有较差的预后。

方法
本项研究是一项前瞻性的随访研究,患者被要求在初步评估时填写问卷,包括医院焦虑和抑郁量表(HADS)。所有患者均被随访并测试了他们随后IBD相关结局不良的结果,如IBD相关住院,急诊室就诊和随访期间皮质类固醇复发疗程。Logistic回归用于多变量分析。

结果
共有440名IBD患者完成了基线调查问卷。其中,125人在基线时有焦虑和/或抑郁。在纵向随访期间预测IBD相关结果差的因素包括初始表现时疾病的严重程度增加,随访时间延长以及初始表现时C-反应蛋白升高。在调整潜在的协变量后,具有异常焦虑分数的IBD患者与没有焦虑升高的患者相比具有较差的IBD相关结果([OR] 3.36,95%CI,1.51-7.48)。与没有抑郁评分升高的患者相比,抑郁症患者的IBD相关结果没有差异(OR 0.43,95%CI,0.14-1.32)。

结论
严重的疾病活动度和焦虑与IBD患者的不良预后有关。

原始出处:
Neeraj Narula. Et al. Anxiety But Not Depression Predicts Poor Outcomes in Inflammatory Bowel Disease. Inflammatory Bowel Diseases.2019.

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    2019-07-08 bnurmamat
  2. [GetPortalCommentsPageByObjectIdResponse(id=1263531, encodeId=e30e126353104, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Mon Jul 08 11:11:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547233, encodeId=fa0c154e233a1, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Mon Jul 08 11:11:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369193, encodeId=5adc3691939c, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Sat Jul 06 23:12:47 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050502, encodeId=528810505028b, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sat Jul 06 23:11:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369181, encodeId=7a7f3691818a, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Jul 06 22:23:29 CST 2019, time=2019-07-06, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1263531, encodeId=e30e126353104, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Mon Jul 08 11:11:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547233, encodeId=fa0c154e233a1, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Mon Jul 08 11:11:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369193, encodeId=5adc3691939c, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Sat Jul 06 23:12:47 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050502, encodeId=528810505028b, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sat Jul 06 23:11:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369181, encodeId=7a7f3691818a, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Jul 06 22:23:29 CST 2019, time=2019-07-06, status=1, ipAttribution=)]
    2019-07-06 百草

    666

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1263531, encodeId=e30e126353104, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Mon Jul 08 11:11:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547233, encodeId=fa0c154e233a1, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Mon Jul 08 11:11:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369193, encodeId=5adc3691939c, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Sat Jul 06 23:12:47 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050502, encodeId=528810505028b, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sat Jul 06 23:11:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369181, encodeId=7a7f3691818a, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Jul 06 22:23:29 CST 2019, time=2019-07-06, status=1, ipAttribution=)]
    2019-07-06 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1263531, encodeId=e30e126353104, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Mon Jul 08 11:11:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547233, encodeId=fa0c154e233a1, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Mon Jul 08 11:11:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369193, encodeId=5adc3691939c, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Sat Jul 06 23:12:47 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050502, encodeId=528810505028b, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sat Jul 06 23:11:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369181, encodeId=7a7f3691818a, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Jul 06 22:23:29 CST 2019, time=2019-07-06, status=1, ipAttribution=)]
    2019-07-06 130****4638

    学习了,谢谢分享。

    0