J Clin Periodontol:牙周炎与阿尔茨海默病风险、轻度认知障碍和主观认知功能减退的关系

2018-11-16 MedSci MedSci原创

本实验旨在检测牙周病是否可以导致轻度认知功能障碍(MCI),主观认知能力下降(SCD)和阿尔茨海默病(AD)风险增加。

本实验旨在检测牙周病是否可以导致轻度认知功能障碍(MCI),主观认知能力下降(SCD)和阿尔茨海默病(AD)风险增加。

方法:该病例对照研究在瑞典Huddinge进行,为期3年。总共有154例患者从卡罗林斯卡大学医院的Karolinska Memory Clinic连续入组,分配到三个诊断组:AD,MCI和SCD。76个认知健康的年龄和性别匹配的个体通过瑞典人口登记册随机纳入对照。所有病例和对照均进行临床和影像学口腔检查。统计分析基于针对潜在混杂因素调整的逻辑回归模型。

结果:口腔健康状况不佳和边缘牙槽骨吸收在病例中比对照组更为普遍。病例组与广泛性边缘牙槽骨吸收相关(优势比[OR] = 5.81; 95%置信区间[CI] = 1.14-29.68),深牙周袋(OR = 8.43; CI 4.00-17.76)和龋齿(OR = 3.36; CI 1.20-9.43)数量增加。

结果表明,边缘性牙周炎与早期认知障碍和AD有关。但是,研究设计并不排除非因果解释。

原始出处:

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    2018-12-18 feather89

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