JACC:人胚胎干细胞来源的心脏祖细胞可用于临床治疗

2018-01-31 MedSci MedSci原创

人类胚胎干细胞(hESCs)由于其全能性,可以定向分化为不同组织特异性的细胞。本研究的目的旨在利用人类胚胎干细胞的特性分化出临床级别的心血管祖细胞,并对其应用在严重缺血性左心功能不全患者上的安全性进行评估。本研究共纳入了6名心功能不全患者(平均年龄66.5岁,平均左室射血分数为26%),所有患者均接受了载有平均820万个hESC来源的心血管祖细胞的纤维蛋白补片治疗,主要终点事件是患者术后1年的安全

人类胚胎干细胞(hESCs)由于其全能性,可以定向分化为不同组织特异性的细胞。本研究的目的旨在利用人类胚胎干细胞的特性分化出临床级别的心血管祖细胞,并对其应用在严重缺血性左心功能不全患者上的安全性进行评估。

本研究共纳入了6名心功能不全患者(平均年龄66.5岁,平均左室射血分数为26%),所有患者均接受了载有平均820万个hESC来源的心血管祖细胞的纤维蛋白补片治疗,主要终点事件是患者术后1年的安全性,主要包括:1)心脏肿瘤的发生;2)心律失常的发生;3)同种异体免疫的发生。患者的平均随访时间为18个月。研究结果显示,1名患者在术后不久死于其他非相关性并发症,剩余患者顺利恢复。最终无心脏肿瘤和心律失常的发生,3名患者出现有临床沉默型同种异体免疫反应,所有患者的心脏收缩功能均有提高。1名患者在术后22个月死于心衰

研究结果显示,利用人类胚胎干细胞分化出临床级别的心血管祖细胞治疗心功能不全患者在早中期是安全可行的。

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    2018-04-21 hbwxf
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    2018-02-02 ailian1202
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