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Neurology：Aβ清除蛋白的SNPs与痴呆症有何关系！

2017-11-09 xing.T MedSci原创

Aβ清除蛋白snps痴呆症
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这项研究表明与Aβ清除有关的遗传变异参与了帕金森病出现老年痴呆症的发病机制，并且可能影响痴呆症的发病。

近日，神经病学领域权威杂志Neurology上发表了一篇研究文章，研究人员旨在评估β-淀粉样蛋白（Aβ）清除蛋白的遗传变异在生物学层面上是否与脑脊液中的β1-42以及在临床层面上是否与帕金森病患者的老年痴呆症发生相关。

研究人员分析了一种已知的参与Aβ清除的遗传变异，帕金森病组包含了456名患者，其中103人患有老年痴呆症。研究人员采用横断面研究的方法评估了APOE、血清胱抑素C（CST）、和膜金属内肽酶（MME）基因的单核苷酸多态性与人口统计变量、临床表型以及脑脊液中β1-42水平之间的相关性。

研究人员发现ApoE和CST基因的危险变异与脑脊液中β1-42水平较低相关。在临床上，CST基因中有2个危险等位基因的个体表现出从帕金森病发病年龄到出现老年痴呆症的年龄间隔时间更短。

这项研究表明与Aβ清除有关的遗传变异参与了帕金森病出现老年痴呆症的发病机制，并且可能影响痴呆症的发病。

原始出处：

Kathrin Brockmann,et al. SNPs in Aβ clearance proteins Lower CSF Aβ1-42 levels and earlier onset of dementia in PD. Neurology. 2017. http://dx.doi.org/10.1212/WNL.0000000000004705

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    2018-08-15 ms3046638856685384

    #snps#

    0

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    2018-09-22 ms1756883563247400

    #NPS#

    0

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    2018-05-06 Boyinsh

    #痴呆症#

    0

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    2018-03-17 yinhl1978

    #Neurol#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1715621, encodeId=cb9e1e15621cc, content=<a href='/topic/show?id=7c0f1649650' target=_blank style='color:#2F92EE;'>#snps#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16496, encryptionId=7c0f1649650, topicName=snps)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5831973326, createdName=ms3046638856685384, createdTime=Wed Aug 15 19:34:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689185, encodeId=c2661689185e5, content=<a href='/topic/show?id=4f5f1301822' target=_blank style='color:#2F92EE;'>#NPS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13018, encryptionId=4f5f1301822, topicName=NPS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=087d28754942, createdName=ms1756883563247400, createdTime=Sat Sep 22 22:34:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836166, encodeId=76121836166ae, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun May 06 20:34:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000164, encodeId=e2a02000164d5, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Mar 17 00:34:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331899, encodeId=3214133189974, content=<a href='/topic/show?id=94e31649430' target=_blank style='color:#2F92EE;'>#SNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16494, encryptionId=94e31649430, topicName=SNP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqcyT7aQIuoYGGYr889lEiaOVWSfvMQ4d2oxhTMlWzEr6lPmg6pxzCVvPScSZrne4JFSyyPRCOxllQ/132, createdBy=416a2500064, createdName=ms3323097325231039, createdTime=Sat Nov 11 09:34:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605258, encodeId=1af4160525899, content=<a href='/topic/show?id=b820309108' target=_blank style='color:#2F92EE;'>#Aβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3091, encryptionId=b820309108, topicName=Aβ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee1c19366172, createdName=膀胱癌, createdTime=Sat Nov 11 09:34:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260453, encodeId=041926045375, content=痴呆症发病因, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Nov 11 08:30:22 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260049, encodeId=d628260049f5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Nov 09 19:29:34 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-11 ms3323097325231039

    #SNP#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1715621, encodeId=cb9e1e15621cc, content=<a href='/topic/show?id=7c0f1649650' target=_blank style='color:#2F92EE;'>#snps#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16496, encryptionId=7c0f1649650, topicName=snps)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5831973326, createdName=ms3046638856685384, createdTime=Wed Aug 15 19:34:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689185, encodeId=c2661689185e5, content=<a href='/topic/show?id=4f5f1301822' target=_blank style='color:#2F92EE;'>#NPS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13018, encryptionId=4f5f1301822, topicName=NPS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=087d28754942, createdName=ms1756883563247400, createdTime=Sat Sep 22 22:34:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836166, encodeId=76121836166ae, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun May 06 20:34:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000164, encodeId=e2a02000164d5, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Mar 17 00:34:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331899, encodeId=3214133189974, content=<a href='/topic/show?id=94e31649430' target=_blank style='color:#2F92EE;'>#SNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16494, encryptionId=94e31649430, topicName=SNP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqcyT7aQIuoYGGYr889lEiaOVWSfvMQ4d2oxhTMlWzEr6lPmg6pxzCVvPScSZrne4JFSyyPRCOxllQ/132, createdBy=416a2500064, createdName=ms3323097325231039, createdTime=Sat Nov 11 09:34:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605258, encodeId=1af4160525899, content=<a href='/topic/show?id=b820309108' target=_blank style='color:#2F92EE;'>#Aβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3091, encryptionId=b820309108, topicName=Aβ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee1c19366172, createdName=膀胱癌, createdTime=Sat Nov 11 09:34:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260453, encodeId=041926045375, content=痴呆症发病因, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Nov 11 08:30:22 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260049, encodeId=d628260049f5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Nov 09 19:29:34 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-11 膀胱癌

    #Aβ#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1715621, encodeId=cb9e1e15621cc, content=<a href='/topic/show?id=7c0f1649650' target=_blank style='color:#2F92EE;'>#snps#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16496, encryptionId=7c0f1649650, topicName=snps)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5831973326, createdName=ms3046638856685384, createdTime=Wed Aug 15 19:34:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689185, encodeId=c2661689185e5, content=<a href='/topic/show?id=4f5f1301822' target=_blank style='color:#2F92EE;'>#NPS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13018, encryptionId=4f5f1301822, topicName=NPS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=087d28754942, createdName=ms1756883563247400, createdTime=Sat Sep 22 22:34:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836166, encodeId=76121836166ae, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun May 06 20:34:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000164, encodeId=e2a02000164d5, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Mar 17 00:34:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331899, encodeId=3214133189974, content=<a href='/topic/show?id=94e31649430' target=_blank style='color:#2F92EE;'>#SNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16494, encryptionId=94e31649430, topicName=SNP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqcyT7aQIuoYGGYr889lEiaOVWSfvMQ4d2oxhTMlWzEr6lPmg6pxzCVvPScSZrne4JFSyyPRCOxllQ/132, createdBy=416a2500064, createdName=ms3323097325231039, createdTime=Sat Nov 11 09:34:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605258, encodeId=1af4160525899, content=<a href='/topic/show?id=b820309108' target=_blank style='color:#2F92EE;'>#Aβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3091, encryptionId=b820309108, topicName=Aβ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee1c19366172, createdName=膀胱癌, createdTime=Sat Nov 11 09:34:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260453, encodeId=041926045375, content=痴呆症发病因, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Nov 11 08:30:22 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260049, encodeId=d628260049f5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Nov 09 19:29:34 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-11 sunfeifeiyang

    痴呆症发病因

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1715621, encodeId=cb9e1e15621cc, content=<a href='/topic/show?id=7c0f1649650' target=_blank style='color:#2F92EE;'>#snps#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16496, encryptionId=7c0f1649650, topicName=snps)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5831973326, createdName=ms3046638856685384, createdTime=Wed Aug 15 19:34:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689185, encodeId=c2661689185e5, content=<a href='/topic/show?id=4f5f1301822' target=_blank style='color:#2F92EE;'>#NPS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13018, encryptionId=4f5f1301822, topicName=NPS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=087d28754942, createdName=ms1756883563247400, createdTime=Sat Sep 22 22:34:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836166, encodeId=76121836166ae, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun May 06 20:34:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000164, encodeId=e2a02000164d5, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Mar 17 00:34:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331899, encodeId=3214133189974, content=<a href='/topic/show?id=94e31649430' target=_blank style='color:#2F92EE;'>#SNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16494, encryptionId=94e31649430, topicName=SNP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqcyT7aQIuoYGGYr889lEiaOVWSfvMQ4d2oxhTMlWzEr6lPmg6pxzCVvPScSZrne4JFSyyPRCOxllQ/132, createdBy=416a2500064, createdName=ms3323097325231039, createdTime=Sat Nov 11 09:34:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605258, encodeId=1af4160525899, content=<a href='/topic/show?id=b820309108' target=_blank style='color:#2F92EE;'>#Aβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3091, encryptionId=b820309108, topicName=Aβ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee1c19366172, createdName=膀胱癌, createdTime=Sat Nov 11 09:34:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260453, encodeId=041926045375, content=痴呆症发病因, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Nov 11 08:30:22 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260049, encodeId=d628260049f5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Nov 09 19:29:34 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-09 131****1460

    学习了受益匪浅

    0