NATURE:成年宿主中的有益微生物群在婴儿早期形成

2018-08-11 海北 MedSci原创

最近,来自德国的研究人员报告了宿主介导的细菌定植调节回路的鉴定,其仅在早期新生儿期起作用,但影响终身微生物群组成。

已有的研究显示,肠道微生物群的改变与几种高度流行的免疫介导和代谢疾病相关,并且涉及IBD%E8%AF%8A%E6%B2%BB%E8%BF%87%E7%A8%8B%E4%B8%AD%E7%9A%84%E8%AF%84%E4%BC%B0-Part%" target="_blank">粪便移植的实验已经表明这种改变在至少一部分这样的条件中具有因果作用。出生后期对于微生物群组成,宿主-微生物相互作用和免疫稳态的发展尤其重要。然而,这种新生儿引发期的潜在分子机制尚未确定。
最近,来自德国的研究人员报告了宿主介导的细菌定植调节回路的鉴定,其仅在早期新生儿期起作用,但影响终身微生物群组成。
研究人员证明了新生小鼠肠上皮细胞中鞭毛蛋白受体Toll样受体5(TLR5)的年龄依赖性表达。使用竞争性定植实验,研究人员证明上皮TLR5介导的REG3γ产生对于定殖鞭毛细菌的反选择是至关重要的。
在新生儿和成年野生型和Tlr5缺陷的无菌小鼠中的比较微生物群转移实验揭示,新生儿TLR5表达在整个生命中强烈影响微生物群的组成。因此,成年宿主中的有益微生物群在婴儿早期形成。
该研究解释了为什么在早期生活中扰乱微生物群建立的环境因素会影响成年期的免疫稳态和健康。

原始出处:
Fulde M et al. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. NATURE 2018, DOI: 10.1038/s41586-018-0395-5

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    2019-04-17 liye789132251
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    2018-08-12 wincls
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    2018-08-11 ylzr123

    感谢小编为我们精心准备了如此精辟的精神大餐,小编辛苦了,点个赞吧!

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    2018-08-11 chinadoctorliu_19344479

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