Adv Healthc Mater:氧化石墨烯 - 铜纳米复合材料涂层多孔CaP支架通过激活Hif-1α进行血管化骨再生

2019-06-21 不详 网络

既往研究已经研究了石墨烯的体外骨诱导能力。然而,基于石墨烯的支架的体内骨修复效果仍然未知。本研究中,研究人员制备水溶性氧化石墨烯-铜纳米复合物(GO-Cu),其用于涂覆多孔磷酸钙(CaP)支架以用于血管化骨再生。结果显示,含有约30nm直径的结晶CuO/Cu2O纳米颗粒的GO-Cu纳米复合材料均匀分布在多孔支架的表面上并保持Cu离子的长期释放。在体外,GO-Cu涂层增强了大鼠骨髓干细胞(BMSC)

既往研究已经研究了石墨烯的体外骨诱导能力。然而,基于石墨烯的支架的体内骨修复效果仍然未知。本研究中,研究人员制备水溶性氧化石墨烯-铜纳米复合物(GO-Cu),其用于涂覆多孔磷酸钙(CaP)支架以用于血管化骨再生。

结果显示,含有约30nm直径的结晶CuO/Cu2O纳米颗粒的GO-Cu纳米复合材料均匀分布在多孔支架的表面上并保持Cu离子的长期释放。在体外,GO-Cu涂层增强了大鼠骨髓干细胞(BMSC)的粘附和成骨分化。还发现通过激活Erk1/2信号传导途径,GO-Cu纳米复合物上调BMSC中Hif-1α的表达,导致VEGF和BMP-2蛋白的分泌。当移植到具有临界尺寸的颅骨缺损的大鼠中时,GO-Cu包被的磷酸钙骨水泥(CPC)支架(CPC / GO-Cu)显著促进血管生成和骨生成。此外,通过组织学切片观察到GO-Cu纳米复合材料被多核巨细胞吞噬。

综上所述,该研究结果表明,GO-Cu纳米复合涂层可用作血管化骨再生的有吸引力的策略。

原始出处:

Zhang W, Chang Q, et al., Graphene Oxide-Copper Nanocomposite-Coated Porous CaP Scaffold for Vascularized Bone Regeneration via Activation of Hif-1α. Adv Healthc Mater. 2016 Jun;5(11):1299-309. doi: 10.1002/adhm.201500824. Epub 2016 Mar 4.

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    2019-07-08 shizhenshan
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createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon Jul 08 10:04:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651607, encodeId=e961165160e71, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Sun May 31 20:04:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054540, encodeId=e36f205454053, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=1644308, encodeId=beed16443084e, content=<a href='/topic/show?id=b3c58958013' target=_blank style='color:#2F92EE;'>#血管化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89580, encryptionId=b3c58958013, topicName=血管化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Sep 08 04:04:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898036, encodeId=1f771898036b6, content=<a href='/topic/show?id=832c404308' target=_blank style='color:#2F92EE;'>#CAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4043, encryptionId=832c404308, topicName=CAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, 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encryptionId=1b34881e59, topicName=HIF-1α)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847f11414102, createdName=changfy, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556041, encodeId=c4ab1556041db, content=<a href='/topic/show?id=b3e98813c3' target=_blank style='color:#2F92EE;'>#HIF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8813, encryptionId=b3e98813c3, topicName=HIF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1707004, encodeId=5d761e07004a5, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Tue Jan 07 20:04:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861326, encodeId=9885186132639, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon Jul 08 10:04:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651607, encodeId=e961165160e71, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Sun May 31 20:04:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054540, encodeId=e36f205454053, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=1644308, encodeId=beed16443084e, content=<a href='/topic/show?id=b3c58958013' target=_blank style='color:#2F92EE;'>#血管化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89580, encryptionId=b3c58958013, topicName=血管化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Sep 08 04:04:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898036, encodeId=1f771898036b6, content=<a href='/topic/show?id=832c404308' target=_blank style='color:#2F92EE;'>#CAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4043, encryptionId=832c404308, topicName=CAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, 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encryptionId=1b34881e59, topicName=HIF-1α)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847f11414102, createdName=changfy, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556041, encodeId=c4ab1556041db, content=<a href='/topic/show?id=b3e98813c3' target=_blank style='color:#2F92EE;'>#HIF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8813, encryptionId=b3e98813c3, topicName=HIF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1707004, encodeId=5d761e07004a5, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Tue Jan 07 20:04:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861326, encodeId=9885186132639, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=1644308, encodeId=beed16443084e, content=<a href='/topic/show?id=b3c58958013' target=_blank style='color:#2F92EE;'>#血管化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89580, encryptionId=b3c58958013, topicName=血管化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Sep 08 04:04:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898036, encodeId=1f771898036b6, content=<a href='/topic/show?id=832c404308' target=_blank style='color:#2F92EE;'>#CAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4043, encryptionId=832c404308, topicName=CAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue Feb 04 17:04:00 CST 2020, time=2020-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472201, encodeId=89e414e2201cd, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522156, encodeId=da981522156e8, content=<a href='/topic/show?id=1b34881e59' target=_blank style='color:#2F92EE;'>#HIF-1α#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8817, encryptionId=1b34881e59, topicName=HIF-1α)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847f11414102, createdName=changfy, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556041, encodeId=c4ab1556041db, content=<a href='/topic/show?id=b3e98813c3' target=_blank style='color:#2F92EE;'>#HIF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8813, encryptionId=b3e98813c3, topicName=HIF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
    2020-02-04 smlt2008
  8. [GetPortalCommentsPageByObjectIdResponse(id=1707004, encodeId=5d761e07004a5, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Tue Jan 07 20:04:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861326, encodeId=9885186132639, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon Jul 08 10:04:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651607, encodeId=e961165160e71, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Sun May 31 20:04:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054540, encodeId=e36f205454053, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 04 18:04:00 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804536, encodeId=58f91804536d4, content=<a href='/topic/show?id=a6fbe737024' target=_blank style='color:#2F92EE;'>#纳米复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77370, encryptionId=a6fbe737024, topicName=纳米复合材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbcc223, createdName=cooco, createdTime=Thu Sep 19 22:04:00 CST 2019, time=2019-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644308, encodeId=beed16443084e, content=<a href='/topic/show?id=b3c58958013' target=_blank style='color:#2F92EE;'>#血管化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89580, encryptionId=b3c58958013, topicName=血管化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Sep 08 04:04:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898036, encodeId=1f771898036b6, content=<a href='/topic/show?id=832c404308' target=_blank style='color:#2F92EE;'>#CAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4043, encryptionId=832c404308, topicName=CAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue Feb 04 17:04:00 CST 2020, time=2020-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472201, encodeId=89e414e2201cd, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522156, encodeId=da981522156e8, content=<a href='/topic/show?id=1b34881e59' target=_blank style='color:#2F92EE;'>#HIF-1α#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8817, encryptionId=1b34881e59, topicName=HIF-1α)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847f11414102, createdName=changfy, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556041, encodeId=c4ab1556041db, content=<a href='/topic/show?id=b3e98813c3' target=_blank style='color:#2F92EE;'>#HIF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8813, encryptionId=b3e98813c3, topicName=HIF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
    2019-06-23 lsj630
  9. [GetPortalCommentsPageByObjectIdResponse(id=1707004, encodeId=5d761e07004a5, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Tue Jan 07 20:04:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861326, encodeId=9885186132639, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, 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GetPortalCommentsPageByObjectIdResponse(id=1644308, encodeId=beed16443084e, content=<a href='/topic/show?id=b3c58958013' target=_blank style='color:#2F92EE;'>#血管化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89580, encryptionId=b3c58958013, topicName=血管化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Sep 08 04:04:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898036, encodeId=1f771898036b6, content=<a href='/topic/show?id=832c404308' target=_blank style='color:#2F92EE;'>#CAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4043, encryptionId=832c404308, topicName=CAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue Feb 04 17:04:00 CST 2020, time=2020-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472201, encodeId=89e414e2201cd, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522156, encodeId=da981522156e8, content=<a href='/topic/show?id=1b34881e59' target=_blank style='color:#2F92EE;'>#HIF-1α#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8817, encryptionId=1b34881e59, topicName=HIF-1α)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847f11414102, createdName=changfy, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556041, encodeId=c4ab1556041db, content=<a href='/topic/show?id=b3e98813c3' target=_blank style='color:#2F92EE;'>#HIF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8813, encryptionId=b3e98813c3, topicName=HIF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
    2019-06-23 changfy
  10. [GetPortalCommentsPageByObjectIdResponse(id=1707004, encodeId=5d761e07004a5, content=<a href='/topic/show?id=d2773359191' target=_blank style='color:#2F92EE;'>#化石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33591, encryptionId=d2773359191, topicName=化石)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d531331396, createdName=ms7899726347904398, createdTime=Tue Jan 07 20:04:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861326, encodeId=9885186132639, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, 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GetPortalCommentsPageByObjectIdResponse(id=1644308, encodeId=beed16443084e, content=<a href='/topic/show?id=b3c58958013' target=_blank style='color:#2F92EE;'>#血管化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89580, encryptionId=b3c58958013, topicName=血管化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Sep 08 04:04:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898036, encodeId=1f771898036b6, content=<a href='/topic/show?id=832c404308' target=_blank style='color:#2F92EE;'>#CAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4043, encryptionId=832c404308, topicName=CAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue Feb 04 17:04:00 CST 2020, time=2020-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472201, encodeId=89e414e2201cd, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522156, encodeId=da981522156e8, content=<a href='/topic/show?id=1b34881e59' target=_blank style='color:#2F92EE;'>#HIF-1α#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8817, encryptionId=1b34881e59, topicName=HIF-1α)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847f11414102, createdName=changfy, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556041, encodeId=c4ab1556041db, content=<a href='/topic/show?id=b3e98813c3' target=_blank style='color:#2F92EE;'>#HIF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8813, encryptionId=b3e98813c3, topicName=HIF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sun Jun 23 14:04:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
    2019-06-23 heli0118