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Exp Cell Res：VDAC1蛋白的调控有助于长托宁对缺血-再灌注心肌的保护作用

2018-04-19 王贵龙 “罂粟花”微信号

长托宁缺血/再灌注心肌保护
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长托宁（PHC）预处理可减轻心肌缺血/再灌注（I/R）损伤并抑制电压依赖性阴离子通道蛋白1（VDAC1）的表达。

背景与目的：长托宁（PHC）预处理可减轻心肌缺血/再灌注（I/R）损伤并抑制电压依赖性阴离子通道蛋白1（VDAC1）的表达。

方法：为了验证VDAC1在PHC介导的心肌I/R损伤中的保护作用，在PHC预处理和心肌I/R之前，将VDAC1表达构建体通过慢病毒转染至大鼠左心室心肌细胞中。

结果：VDAC1的过度表达加剧了I/R后的心脏功能障碍和心肌损伤，并且在I/R损伤期间PHC的心脏保护作用受抑制；此外，I/R心肌的VDAC1过度表达进一步增加细胞色素C从线粒体释放到细胞质，从而增加了半胱氨酸蛋白酶-3和Bax的表达水平、降低Bcl-2的表达水平；与单独I/R相比，PHC可抑制VDAC1过表达的心肌I/R期间线粒体依赖性细胞的凋亡，此外，经过PHC的预处理，缺氧/复氧（A /R）的H9c2心肌细胞VDAC1过度表达受抑制。体外实验结果进一步表明，VDAC1的过表达降低了A/R后H9c2细胞线粒体膜电位，线粒体膜通透性增加以及线粒体依赖性细胞的凋亡增加，并且VDAC1过表达抑制了PHC对A/ R期间线粒体功能和完整性的保护作用。

结论：心肌I/R期间，VDAC1的外源性过表达会抑制PHC的心肌保护作用，这可能与PHC抑制VDAC1的表达有关。

原始出处：

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1870582, encodeId=684618e058271, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun May 06 01:34:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078279, encodeId=693020e8279fa, content=<a href='/topic/show?id=ea89969192d' target=_blank style='color:#2F92EE;'>#长托宁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96919, encryptionId=ea89969192d, topicName=长托宁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Thu Nov 08 08:34:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960851, encodeId=0dec1960851dd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Mar 17 08:34:00 CST 2019, time=2019-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599082, encodeId=bdcf1599082dc, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Sat Apr 21 04:34:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307314, encodeId=98ad30e314b5, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Thu Apr 19 16:42:12 CST 2018, time=2018-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307287, encodeId=537630e287d5, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Thu Apr 19 13:47:13 CST 2018, time=2018-04-19, status=1, ipAttribution=)]
    2018-05-06 zhaozhouchifen

    #Cell#

    0

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    2018-11-08 yyanpro@21cn.c

    #长托宁#

    0

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    2019-03-17 维他命

    #CEL#

    0

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    2018-04-21 photoman

    #保护作用#

    0

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    2018-04-19 戒馋，懒，贪

    谢谢分享学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1870582, encodeId=684618e058271, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun May 06 01:34:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078279, encodeId=693020e8279fa, content=<a href='/topic/show?id=ea89969192d' target=_blank style='color:#2F92EE;'>#长托宁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96919, encryptionId=ea89969192d, topicName=长托宁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Thu Nov 08 08:34:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960851, encodeId=0dec1960851dd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Mar 17 08:34:00 CST 2019, time=2019-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599082, encodeId=bdcf1599082dc, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Sat Apr 21 04:34:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307314, encodeId=98ad30e314b5, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Thu Apr 19 16:42:12 CST 2018, time=2018-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307287, encodeId=537630e287d5, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Thu Apr 19 13:47:13 CST 2018, time=2018-04-19, status=1, ipAttribution=)]
    2018-04-19 jihuaijun1112

    学习学习学习

    0