ACC 2018:两种降压药物或增死亡风险,血压波动大注意调整药物

2018-03-16 文韬 中国循环杂志

2018 年美国心脏病学会(ACC)学术年会上,美国Clements等报告,使用α受体阻滞剂和中枢性α- 2受体激动剂降压治疗的患者血压变异性增加,从而可能会增加死亡风险。

2018 年美国心脏病学会(ACC)学术年会上,美国Clements等报告,使用α受体阻滞剂和中枢性α- 2受体激动剂降压治疗的患者血压变异性增加,从而可能会增加死亡风险。

作者建议,这两种药物不应用于降压治疗。

α受体阻滞剂,主要包括多沙唑嗪和哌唑嗪,可扩张血管。α- 2受体激动剂,如甲基多巴,是中枢降压药物,针对交感神经系统活性,从而减少血管收缩。

研究人员分析了2007年1月到2011年12月间入选ALLHAERT研究的10903名高血压患者,每人至少测量了七次血压,并记录了这些患者的降压药物。

研究发现应用α受体阻滞剂和中枢性α-2受体激动剂的患者血压变异性较高。

血压变异性是指患者在一定时间内血压波动的程度。血压变异性按照观察时间的长短可分为短时变异性和长时变异性。

短时变异性指24小时内同次就诊血压变异和昼夜血压的变化。长时血压变异性是指数日间变异(家庭自测血压变异)、数周间变异(随诊间血压变异)和数月甚至季节间血压变异等。

在Clements等的另一项研究中,作者将诊室血压变异程度(OBPV)分为<13.3、13.3~16.4、16.4~19、19-22.7和>22.7 mmHg五组。

结果发现,诊室血压变异程度越大,患者的死亡率越高。



多因素校正后,诊室血压变异程度>13.3 mmHg的患者未来发生死亡的风险增加10%~15%。

作者表示,如果患者血压波动比较大,应与医生沟通,更换降压方案。

也有研究证明,短期和长期血压变异性增加,均与心脑血管事件和全因死亡独立相关,随诊期间血压变异性是心血管事件强预测因素,其作用独立于平均血压之外。

原始出处:
[1]New Definitions of Visit-to-Visit Office Blood Pressure Variability and its Effect on All-Cause Mortality. ACC 2018.
[2]Does Office Blood Pressure Variability Predict Mortality Among Antihypertensive Classes.ACC 2018.

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    2018-03-17 1209e435m98(暂无昵称)

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