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Nat Commun：女性生殖道微生物监测或可评估上生殖道疾病的发生

2017-10-22 MedSci MedSci原创

微生物生殖道
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研究发现怀孕期间母体体液中检测到的细菌通常与不良结局有关，而且女性生殖道除阴道以外是否拥有独特的微生物群落则存在争议。本研究中，研究人员系统地对110名育龄妇女的女性生殖道内的微生物进行抽样，并通过16S rRNA基因扩增子测序和培养来检查定殖微生物的性质。结果，研究人员发现，在子宫颈管、子宫、输卵管和腹膜液中存在不同于阴道的微生物群落。结果反映了女性生殖道存在连续的微生物群落分布，表明并非无菌环

研究发现怀孕期间母体体液中检测到的细菌通常与不良结局有关，而且女性生殖道除阴道以外是否拥有独特的微生物群落则存在争议。

本研究中，研究人员系统地对110名育龄妇女的女性生殖道内的微生物进行抽样，并通过16S rRNA基因扩增子测序和培养来检查定殖微生物的性质。

结果，研究人员发现，在子宫颈管、子宫、输卵管和腹膜液中存在不同于阴道的微生物群落。结果反映了女性生殖道存在连续的微生物群落分布，表明并非无菌环境。此外，研究人员还确定与月经周期相关的微生物分类群和潜在功能，或在子宫内膜异位症或子宫内膜异位症不孕患者中过度表达。

总之，该研究结果提供了对阴道-子宫微生物组织的性质的了解，并建议对阴道或子宫颈微生物群进行评估可能有助于检测上生殖道中的常见疾病。

原始出处：

Chen Chen, Xiaolei Song, et al., The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat Commun. 2017; 8: 875. Published online 2017 Oct 17. doi: 10.1038/s41467-017-00901-0

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    2018-01-11 wjcjjian

    #微生物#

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    2018-04-27 124984e7m93暂无昵称

    #生殖道#

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    2018-03-09 liuli5079

    #COMMUN#

    0

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encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Apr 29 17:28:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258072, encodeId=1c8c2580e2d5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Thu Nov 02 12:59:01 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531896, encodeId=c791153189616, content=<a href='/topic/show?id=0579446550d' target=_blank style='color:#2F92EE;'>#女性生殖#</a>, beContent=null, objectType=article, channel=null, level=null, 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Oct 22 17:57:12 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2018-04-29 liye789132251

    #Nat#

    0

  5. 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Oct 22 17:57:12 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2017-11-02 海之蓝

    学习

    0

  6. 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Oct 22 17:57:12 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2017-10-24 slcumt

    #女性生殖#

    0

  7. 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Oct 22 17:57:12 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2017-10-23 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

  8. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Oct 22 21:06:24 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255135, encodeId=96da255135a1, content=学习一下.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Oct 22 18:00:30 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255131, encodeId=4fd425513158, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Oct 22 17:57:12 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2017-10-22 三生有幸9135

    学习一下谢谢分享

    0

  9. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Oct 22 21:06:24 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255135, encodeId=96da255135a1, content=学习一下.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Oct 22 18:00:30 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255131, encodeId=4fd425513158, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Oct 22 17:57:12 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2017-10-22 changjiu

    学习一下.谢谢

    0

  10. 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Oct 22 17:57:12 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
    2017-10-22 戒馋，懒，贪

    谢谢分享

    0

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Microbiome：太空舱内微生物群变化可能影响宇航员健康

如果要开展前往火星的载人航天任务，宇航员需要在密闭太空舱内长时间生活。一个国际团队在英国《微生物组》杂志上发表新研究说，太空舱内微生物群数量和种类变化，对未来长期太空旅行中创造一个健康、稳定的环境起着重要作用。

Oncotarget：微生物研究新突破，用益生菌或抗生素预防乳腺癌！

在一项最新发表的研究中，克利夫兰诊所的研究人员揭示了健康女性与乳腺癌女性乳腺组织中细菌组成的差异。相关内容于10月5日在线发表在Oncotarget，该项研究由Doris Duke慈善基金会、肿瘤外科基金会、克利夫兰Taussig癌症研究所、Earlier.org等共同资助完成。

GUT：口腔微生物竟然可以预测结肠直肠癌！

微生物群落的变化与结肠直肠癌（CRC）密切相关，特别是在结肠肿瘤患者中，可能具有较高的口腔细菌丰富度。然而，目前尚不知道结肠粘膜相关的分类群是否确实是口腔中衍生的，这种情况是否是患者的独特情况，亦或者口腔微生物群体适合用于筛选CRC患者。近期，一项发表在杂志GUT的研究从CRC患者（99名受试者），结肠直肠息肉患者（32名）或对照组（103名）的个体中分析口腔拭子、结肠粘膜和粪便中的微生物群情况。

Oncotarget：乳腺癌患者具有不同的乳腺微生物群

乳腺癌是在全球妇女中最常见的癌症，但是至今为止，至少有一半的患病妇女没有已知的危险因素。只有一部分患者因为乳腺癌遗传倾向，或是暴露于已知的环境危险因素而患病。因此，我们还需要进一步确定其他的乳腺癌危险因素。

mSphere：细菌之外，真菌也和肥胖相关

最近的研究显示，肠道微生物与肥胖现象息息相关。肥胖是全球日益增长的健康问题。其与心血管疾病的风险增加有关。但是，最近的关于微生物和代谢的研究主要局限在对细菌的分析。人们似乎不约而同地忽略了真菌对于健康代谢的潜在贡献。至今为止，几乎没有研究去探索真菌对于肥胖症的作用。