Lancet Infect Dis:HIV相关隐球菌性脑膜炎全球流行病学

2017-05-06 zhangfan MedSci原创

全球,特别是在撒哈拉以南非洲,艾滋病相关的隐球菌病负担日益严重,撒哈拉以南非洲隐球菌性脑膜炎盛行是地区艾滋病治疗方案失败的体现应针对该情况采取相应的国际援助

成人新型隐球菌脑膜炎是撒哈拉以南非洲最常见的艾滋病感染者的并发症,近日研究人员就该疾病的全球流行情况进行了研究。

研究人员使用联合国艾滋病防治计划记录的2014年成人HIV和抗逆转录病毒疗法(ART)的数据,估计中低收入和中等收入国家CD4细胞数量小于100/μL,病毒学治疗失败率以及后续损失情况,计算隐球菌感染的风险,特别是那些CD4细胞数量小于100/μL以及病毒学治疗失败的患者。

研究估计全球CD4细胞数量小于100/μL人群中,平均隐球菌抗原血症的患病率为6.0%(95% CI 5.8-6.2),全球约有278000人(95% CI 195500-340600)隐球菌抗原阳性,2014年新发的隐球菌抗原阳性病例223100 (95% CI 150600-282400),其中有73%发生在撒哈拉以南的非洲(162500 起 [95% CI 113600-193900])。估计全球每年死于隐球菌脑膜炎的人数约181100(95% CI 119400-234300),其中撒哈拉以南的非洲死亡135900人(75%; [95% CI 93900-163900])。在全球范围内,新型隐球菌性脑膜炎导致约15%的艾滋病人死亡(95% CI 10%-19%)。

研究表明全球,特别是在撒哈拉以南非洲,艾滋病相关的隐球菌病负担日益严重,撒哈拉以南非洲隐球菌性脑膜炎盛行是地区艾滋病治疗方案失败的体现应针对该情况采取相应的国际援助。

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    2017-07-07 howi
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    2017-05-08 xugumin
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    2017-05-08 xugc
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    2017-05-06 dhzzm

    学习了分享了,很好

    0

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    2017-05-06 飛歌

    学习了很有用

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